P-115: Unc-51 Like Kinase 3 protein (ULK3)-mediated autophagy is responsible for multiple myeloma resistance to chemotherapy

por Tauro, Marilena, Li, Tao, Meads, Mark, Sudalagunta, Praneeth, Alugubelli, Raghunandan Reddy, Lawrence, Nicholas, Schonbrunn, Ernst, Lawrence, Harshani, Shain, Kenneth, Lynch, Conor
Publicado 2022

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors

por Turner, Joel G., Dawson, Jana L., Grant, Steven, Shain, Kenneth H., Dalton, William S., Dai, Yun, Meads, Mark, Baz, Rachid, Kauffman, Michael, Shacham, Sharon, Sullivan, Daniel M.
Publicado 2016

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myel...

por Turner, Joel G., Kashyap, Trinayan, Dawson, Jana L., Gomez, Juan, Bauer, Alexis A., Grant, Steven, Dai, Yun, Shain, Kenneth H., Meads, Mark, Landesman, Yosef, Sullivan, Daniel M.
Publicado 2016

A pharmacodynamic model of clinical synergy in multiple myeloma

por Sudalagunta, Praneeth, Silva, Maria C., Canevarolo, Rafael R., Alugubelli, Raghunandan Reddy, DeAvila, Gabriel, Tungesvik, Alexandre, Perez, Lia, Gatenby, Robert, Gillies, Robert, Baz, Rachid, Meads, Mark B., Shain, Kenneth H., Silva, Ariosto S.
Publicado 2020

Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma

por Hasipek, Metis, Grabowski, Dale, Guan, Yihong, Alugubelli, Raghunandan Reddy, Tiwari, Anand D., Gu, Xiaorong, DeAvila, Gabriel A., Silva, Ariosto S., Meads, Mark B., Parker, Yvonne, Lindner, Daniel J., Saunthararajah, Yogen, Shain, Kenneth H., Maciejewski, Jaroslaw P., Reu, Frederic J., Phillips, James G., Jha, Babal K.
Publicado 2021

Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma

por Zhao, Xiaohong, Wang, Michelle Y., Jiang, Huijuan, Lwin, Tint, Park, Paul M., Gao, Jing, Meads, Mark B., Ren, Yuan, Li, Tao, Sun, Jiao, Fahmi, Naima Ahmed, Singh, Satishkumar, Sehgal, Lalit, Wang, Xuefeng, Silva, Ariosto S., Sotomayor, Eduardo M., Shain, Kenneth H., Cleveland, John L., Wang, Michael, Zhang, Wei, Qi, Jun, Shah, Bijal D., Tao, Jianguo
Publicado 2021

Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma

por Zhao, Xiaohong, Lwin, Tint, Silva, Ariosto, Shah, Bijal, Tao, Jiangchuan, Fang, Bin, Zhang, Liang, Fu, Kai, Bi, Chengfeng, Li, Jiannong, Jiang, Huijuan, Meads, Mark B., Jacobson, Timothy, Silva, Maria, Distler, Allison, Darville, Lancia, Zhang, Ling, Han, Ying, Rebatchouk, Dmitri, Di Liberto, Maurizio, Moscinski, Lynn C., Koomen, John M., Dalton, William S., Shain, Kenneth H., Wang, Michael, Sotomayor, Eduardo, Tao, Jianguo
Publicado 2017

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

por Burger, Karen L., Fernandez, Mario R., Meads, Mark B., Sudalagunta, Praneeth, Oliveira, Paula S., Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I., Dai, Hongyue A., Vincelette, Nicole D., Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M., Roush, William R., Monastyrskyi, Andrii, Berglund, Anders E., Silva, Ariosto S., Cleveland, John L., Shain, Kenneth H.
Publicado 2023

Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma

por Mostofa, AGM, Distler, Allison, Meads, Mark B., Sahakian, Eva, Powers, John J., Achille, Alexandra, Noyes, David, Wright, Gabriela, Fang, Bin, Izumi, Victoria, Koomen, John, Rampakrishnan, Rupal, Nguyen, Tuan P., De Avila, Gabriel, Silva, Ariosto S., Sudalagunta, Praneeth, Canevarolo, Rafael Renatino, Siqueira Silva, Maria D. Coelho, Alugubelli, Raghunandan Reddy, Dai, Hongyue A., Kulkarni, Amit, Dalton, William S., Hampton, Oliver A., Welsh, Eric A., Teer, Jamie K., Tungesvik, Alexandre, Wright, Kenneth L., Pinilla-Ibarz, Javier, Sotomayor, Eduardo M., Shain, Kenneth H., Brayer, Jason
Publicado 2021