The pyridazine heterocycle in molecular recognition and drug discovery

por Meanwell, Nicholas A.
Publicado 2023

The Influence of Bioisosteres in Drug Design: Tactical Applications to Address Developability Problems

por Meanwell, Nicholas A.
Publicado 2014

The Discovery and Development of Daclatasvir: An Inhibitor of the Hepatitis C Virus NS5A Replication Complex

por Meanwell, Nicholas A., Belema, Makonen
Publicado 2018

Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir

por Wang, Tao, Kadow, John F., Meanwell, Nicholas A.
Publicado 2021

Chapter 22. Non-HIV antiviral agents

por Meanwell, Nicholas A., Serrano-Wu, Michael H., Snyder, Lawrence B.
Publicado 2003

The Discovery and Early Clinical Evaluation of the HCV NS3/4A Protease Inhibitor Asunaprevir (BMS-650032)

por Meanwell, Nicholas A., Rajamani, Ramkumar, Scola, Paul M., Sun, Li-Qiang
Publicado 2018

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

por Lambert, Sebastian M, Langley, David R, Garnett, James A, Angell, Richard, Hedgethorne, Katy, Meanwell, Nicholas A, Matthews, Steve J
Publicado 2014

Ligand‐Enabled β‐C(sp(3))−H Lactamization of Tosyl‐Protected Aliphatic Amides Using a Practical Oxidant

por Zhuang, Zhe, Liu, Shuang, Cheng, Jin‐Tang, Yeung, Kap‐Sun, Qiao, Jennifer X., Meanwell, Nicholas A., Yu, Jin‐Quan
Publicado 2022

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

por Langley, David R, Roy Kimura, S, Sivaprakasam, Prasanna, Zhou, Nannan, Dicker, Ira, McAuliffe, Brian, Wang, Tao, Kadow, John F, Meanwell, Nicholas A, Krystal, Mark
Publicado 2015

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile

por Dicker, Ira, Jeffrey, Jerry L., Protack, Tricia, Lin, Zeyu, Cockett, Mark, Chen, Yan, Sit, Sing-Yuen, Gartland, Martin, Meanwell, Nicholas A., Regueiro-Ren, Alicia, Drexler, Dieter, Cantone, Joseph, McAuliffe, Brian, Krystal, Mark
Publicado 2022

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

por Lin, Zeyu, Cantone, Joseph, Lu, Hao, Nowicka-Sans, Beata, Protack, Tricia, Yuan, Tian, Yang, Hong, Liu, Zheng, Drexler, Dieter, Regueiro-Ren, Alicia, Meanwell, Nicholas A., Cockett, Mark, Krystal, Mark, Lataillade, Max, Dicker, Ira B.
Publicado 2016

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry

por Baldick, Carl J., Wichroski, Michael J., Pendri, Annapurna, Walsh, Ann W., Fang, Jie, Mazzucco, Charles E., Pokornowski, Kevin A., Rose, Ronald E., Eggers, Betsy J., Hsu, Mayla, Zhai, Weixu, Zhai, Guangzhi, Gerritz, Samuel W., Poss, Michael A., Meanwell, Nicholas A., Cockett, Mark I., Tenney, Daniel J.
Publicado 2010

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

por Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J., Chen, Jie, Venables, Brian L., Healy, Matthew, Meanwell, Nicholas A., Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B.
Publicado 2016

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

por Gao, Min, Nettles, Richard E., Belema, Makonen, Snyder, Lawrence B., Nguyen, Van N., Fridell, Robert A., Serrano-Wu, Michael H., Langley, David R., Sun, Jin-Hua, O’Boyle II, Donald R., Lemm, Julie A., Wang, Chunfu, Knipe, Jay O., Chien, Caly, Colonno, Richard J., Grasela, Dennis M., Meanwell, Nicholas A., Hamann, Lawrence G.
Publicado 2010