A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation

por Mega, Alessandro, Mebrahtu, Aman, Aniander, Gustav, Ryer, Eva, Sköld, Annette, Sandegren, Anna, Backström Rydin, Eva, Rockberg, Johan, Östman, Arne, Frejd, Fredrik Y.
Publicado 2023

Systematic use of synthetic 5′-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories

por Eisenhut, Peter, Mebrahtu, Aman, Moradi Barzadd, Mona, Thalén, Niklas, Klanert, Gerald, Weinguny, Marcus, Sandegren, Anna, Su, Chao, Hatton, Diane, Borth, Nicole, Rockberg, Johan
Publicado 2020

Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

por Zhan, Caijuan, Bidkhori, Gholamreza, Schwarz, Hubert, Malm, Magdalena, Mebrahtu, Aman, Field, Ray, Sellick, Christopher, Hatton, Diane, Varley, Paul, Mardinoglu, Adil, Rockberg, Johan, Chotteau, Veronique
Publicado 2020

Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination

por Volk, Anna-Luisa, Mebrahtu, Aman, Ko, Bong-Kook, Lundqvist, Magnus, Karlander, Maximilian, Lee, Hyun-Jong, Frejd, Fredrik Y., Kim, Kyu-Tae, Lee, Jong-Seo, Rockberg, Johan
Publicado 2021

Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells

por Ding, Mei, Malhotra, Rajneesh, Ottosson, Tomas, Lundqvist, Magnus, Mebrahtu, Aman, Brengdahl, Johan, Gehrmann, Ulf, Bäck, Elisabeth, Ross-Thriepland, Douglas, Isaksson, Ida, Magnusson, Björn, Sachsenmeier, Kris F., Tegel, Hanna, Hober, Sophia, Uhlén, Mathias, Mayr, Lorenz M., Davies, Rick, Rockberg, Johan, Schiavone, Lovisa Holmberg
Publicado 2021

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

por Malm, Magdalena, Kuo, Chih-Chung, Barzadd, Mona Moradi, Mebrahtu, Aman, Wistbacka, Num, Razavi, Ronia, Volk, Anna-Luisa, Lundqvist, Magnus, Kotol, David, Tegel, Hanna, Hober, Sophia, Edfors, Fredrik, Gräslund, Torbjörn, Chotteau, Veronique, Field, Ray, Varley, Paul G., Roth, Robert G., Lewis, Nathan E., Hatton, Diane, Rockberg, Johan
Publicado 2022