Shooting at a Moving Target—Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development

por Günl, Franziska, Mecate-Zambrano, Angeles, Rehländer, Selina, Hinse, Saskia, Ludwig, Stephan, Brunotte, Linda
Publicado 2021

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro

por Schloer, Sebastian, Brunotte, Linda, Mecate‐Zambrano, Angeles, Zheng, Shuyu, Tang, Jing, Ludwig, Stephan, Rescher, Ursula
Publicado 2021

Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro

por Brunotte, Linda, Zheng, Shuyu, Mecate-Zambrano, Angeles, Tang, Jing, Ludwig, Stephan, Rescher, Ursula, Schloer, Sebastian
Publicado 2021

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

por Schloer, Sebastian, Brunotte, Linda, Goretzko, Jonas, Mecate-Zambrano, Angeles, Korthals, Nadia, Gerke, Volker, Ludwig, Stephan, Rescher, Ursula
Publicado 2020

SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

por Menuchin-Lasowski, Yotam, Schreiber, André, Lecanda, Aarón, Mecate-Zambrano, Angeles, Brunotte, Linda, Psathaki, Olympia E., Ludwig, Stephan, Rauen, Thomas, Schöler, Hans R.
Publicado 2022

The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses

por Schreiber, André, Viemann, Dorothee, Schöning, Jennifer, Schloer, Sebastian, Mecate Zambrano, Angeles, Brunotte, Linda, Faist, Aileen, Schöfbänker, Michael, Hrincius, Eike, Hoffmann, Helen, Hoffmann, Markus, Pöhlmann, Stefan, Rescher, Ursula, Planz, Oliver, Ludwig, Stephan
Publicado 2022

Discrete spatio-temporal regulation of tyrosine phosphorylation directs influenza A virus M1 protein towards its function in virion assembly

por Mecate-Zambrano, Angeles, Sukumar, Swathi, Seebohm, Guiscard, Ciminski, Kevin, Schreiber, André, Anhlan, Darisuren, Greune, Lilo, Wixler, Ludmilla, Grothe, Stephanie, Stein, Nora Caroline, Schmidt, M. Alexander, Langer, Klaus, Schwemmle, Martin, Shi, Tianlai, Ludwig, Stephan, Boergeling, Yvonne
Publicado 2020

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier

por Faist, Aileen, Schloer, Sebastian, Mecate-Zambrano, Angeles, Janowski, Josua, Schreiber, André, Boergeling, Yvonne, Conrad, Beate C.G., Kumar, Sriram, Toebben, Leonie, Schughart, Klaus, Baumgardt, Morris, Kessler, Mirjana, Hoenzke, Katja, Hocke, Andreas, Trautmann, Marcel, Hartmann, Wolfgang, Kato, Hiroki, Rescher, Ursula, Christersson, Anmari, Kuehn, Joachim, Mellmann, Alexander, Wolff, Thorsten, Kuempers, Philip, Rovas, Alexandros, Wiewrodt, Rainer, Wiebe, Karsten, Barth, Peter, Ludwig, Stephan, Brunotte, Linda
Publicado 2023

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

por Hönzke, Katja, Obermayer, Benedikt, Mache, Christin, Fathykova, Diana, Kessler, Mirjana, Dökel, Simon, Wyler, Emanuel, Baumgardt, Morris, Löwa, Anna, Hoffmann, Karen, Graff, Patrick, Schulze, Jessica, Mieth, Maren, Hellwig, Katharina, Demir, Zeynep, Biere, Barbara, Brunotte, Linda, Mecate-Zambrano, Angeles, Bushe, Judith, Dohmen, Melanie, Hinze, Christian, Elezkurtaj, Sefer, Tönnies, Mario, Bauer, Torsten T., Eggeling, Stephan, Tran, Hong-Linh, Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Schmidt-Ott, Kai M., Busch, Jonas, Klauschen, Frederick, Horst, David, Radbruch, Helena, Radke, Josefine, Heppner, Frank, Corman, Victor M., Niemeyer, Daniela, Müller, Marcel A., Goffinet, Christine, Mothes, Ronja, Pascual-Reguant, Anna, Hauser, Anja Erika, Beule, Dieter, Landthaler, Markus, Ludwig, Stephan, Suttorp, Norbert, Witzenrath, Martin, Gruber, Achim D., Drosten, Christian, Sander, Leif-Erik, Wolff, Thorsten, Hippenstiel, Stefan, Hocke, Andreas C.
Publicado 2022