The rapidly evolving view of lysosomal storage diseases

por Parenti, Giancarlo, Medina, Diego L, Ballabio, Andrea
Publicado 2021

The Regulation of MiTF/TFE Transcription Factors Across Model Organisms: from Brain Physiology to Implication for Neurodegeneration

por Agostini, Francesco, Agostinis, Rossella, Medina, Diego L., Bisaglia, Marco, Greggio, Elisa, Plotegher, Nicoletta
Publicado 2022

Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses

por Sirci, Francesco, Napolitano, Francesco, Pisonero-Vaquero, Sandra, Carrella, Diego, Medina, Diego L., di Bernardo, Diego
Publicado 2017

A reverse-engineering approach to dissect post-translational modulators of transcription factor’s activity from transcriptional data

por Gambardella, Gennaro, Peluso, Ivana, Montefusco, Sandro, Bansal, Mukesh, Medina, Diego L., Lawrence, Neil, di Bernardo, Diego
Publicado 2015

TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry

por Sbano, Luigi, Bonora, Massimo, Marchi, Saverio, Baldassari, Federica, Medina, Diego L., Ballabio, Andrea, Giorgi, Carlotta, Pinton, Paolo
Publicado 2017

Cellular and Gene Expression Response to the Combination of Genistein and Kaempferol in the Treatment of Mucopolysaccharidosis Type I

por Węsierska, Magdalena, Kloska, Anna, Medina, Diego L., Jakóbkiewicz-Banecka, Joanna, Gabig-Cimińska, Magdalena, Radzińska, Marta, Moskot, Marta, Malinowska, Marcelina
Publicado 2022

EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation

por Cesana, Marcella, Tufano, Gennaro, Panariello, Francesco, Zampelli, Nicolina, Ambrosio, Susanna, De Cegli, Rossella, Mutarelli, Margherita, Vaccaro, Lorenzo, Ziller, Micheal J., Cacchiarelli, Davide, Medina, Diego L., Ballabio, Andrea
Publicado 2023

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

por Medina, Diego L., Fraldi, Alessandro, Bouche, Valentina, Annunziata, Fabio, Mansueto, Gelsomina, Spampanato, Carmine, Puri, Claudia, Pignata, Antonella, Martina, Jose A., Sardiello, Marco, Palmieri, Michela, Polishchuk, Roman, Puertollano, Rosa, Ballabio, Andrea
Publicado 2011

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

por Settembre, Carmine, Zoncu, Roberto, Medina, Diego L, Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C, Facchinetti, Valeria, Sabatini, David M, Ballabio, Andrea
Publicado 2012

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Interventio...

por Calamita, Piera, Miluzio, Annarita, Russo, Arianna, Pesce, Elisa, Ricciardi, Sara, Khanim, Farhat, Cheroni, Cristina, Alfieri, Roberta, Mancino, Marilena, Gorrini, Chiara, Rossetti, Grazisa, Peluso, Ivana, Pagani, Massimiliano, Medina, Diego L., Rommens, Johanna, Biffo, Stefano
Publicado 2017

The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1

por Venditti, Rossella, Masone, Maria Chiara, Rega, Laura Rita, Di Tullio, Giuseppe, Santoro, Michele, Polishchuk, Elena, Serrano, Ivan Castello, Olkkonen, Vesa M., Harada, Akihiro, Medina, Diego L., La Montagna, Raffaele, De Matteis, Maria Antonietta
Publicado 2019

Automatic identification of small molecules that promote cell conversion and reprogramming

por Napolitano, Francesco, Rapakoulia, Trisevgeni, Annunziata, Patrizia, Hasegawa, Akira, Cardon, Melissa, Napolitano, Sara, Vaccaro, Lorenzo, Iuliano, Antonella, Wanderlingh, Luca Giorgio, Kasukawa, Takeya, Medina, Diego L., Cacchiarelli, Davide, Gao, Xin, di Bernardo, Diego, Arner, Erik
Publicado 2021

NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program

por FitzPatrick, Lorna M., Hawkins, Kate E., Delhove, Juliette M.K.M., Fernandez, Emilio, Soldati, Chiara, Bullen, Louise F., Nohturfft, Axel, Waddington, Simon N., Medina, Diego L., Bolaños, Juan P., McKay, Tristan R.
Publicado 2018

Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

por Mariniello, Marta, Petruzzelli, Raffaella, Wanderlingh, Luca G., La Montagna, Raffaele, Carissimo, Annamaria, Pane, Francesca, Amoresano, Angela, Ilyechova, Ekaterina Y., Galagudza, Michael M., Catalano, Federico, Crispino, Roberta, Puchkova, Ludmila V., Medina, Diego L., Polishchuk, Roman S.
Publicado 2020

Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB

por Medina, Diego L., Di Paola, Simone, Peluso, Ivana, Armani, Andrea, De Stefani, Diego, Venditti, Rossella, Montefusco, Sandro, Scotto-Rosato, Anna, Prezioso, Carolina, Forrester, Alison, Settembre, Carmine, Wang, Wuyang, Gao, Qiong, Xu, Haoxing, Sandri, Marco, Rizzuto, Rosario, De Matteis, Maria Antonietta, Ballabio, Andrea
Publicado 2015

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

por De Leo, Maria Giovanna, Staiano, Leopoldo, Vicinanza, Mariella, Luciani, Alessandro, Carissimo, Annamaria, Mutarelli, Margherita, Di Campli, Antonella, Polishchuk, Elena, Di Tullio, Giuseppe, Morra, Valentina, Levtchenko, Elena, Oltrabella, Francesca, Starborg, Tobias, Santoro, Michele, Di Bernardo, Diego, Devuyst, Olivier, Lowe, Martin, Medina, Diego L., Ballabio, Andrea, De Matteis, Maria Antonietta
Publicado 2016

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

por Contreras, Pablo S., Tapia, Pablo J., González-Hódar, Lila, Peluso, Ivana, Soldati, Chiara, Napolitano, Gennaro, Matarese, Maria, Heras, Macarena Las, Valls, Cristian, Martinez, Alexis, Balboa, Elisa, Castro, Juan, Leal, Nancy, Platt, Frances M., Sobota, Andrzej, Winter, Dominic, Klein, Andrés D., Medina, Diego L., Ballabio, Andrea, Alvarez, Alejandra R., Zanlungo, Silvana
Publicado 2020

Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function

por Piol, Diana, Tosatto, Laura, Zuccaro, Emanuela, Anderson, Eric N., Falconieri, Antonella, Polanco, Maria J., Marchioretti, Caterina, Lia, Federica, White, Joseph, Bregolin, Elisa, Minervini, Giovanni, Parodi, Sara, Salvatella, Xavier, Arrigoni, Giorgio, Ballabio, Andrea, La Spada, Albert R., Tosatto, Silvio C. E., Sambataro, Fabio, Medina, Diego L., Pandey, Udai B., Basso, Manuela, Pennuto, Maria
Publicado 2023

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

por Soldati, Chiara, Lopez‐Fabuel, Irene, Wanderlingh, Luca G, Garcia‐Macia, Marina, Monfregola, Jlenia, Esposito, Alessandra, Napolitano, Gennaro, Guevara‐Ferrer, Marta, Scotto Rosato, Anna, Krogsaeter, Einar K, Paquet, Dominik, Grimm, Christian M, Montefusco, Sandro, Braulke, Thomas, Storch, Stephan, Mole, Sara E, De Matteis, Maria A, Ballabio, Andrea, Sampaio, Julio L, McKay, Tristan, Johannes, Ludger, Bolaños, Juan P, Medina, Diego L
Publicado 2021

Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis

por Lopez-Fabuel, Irene, Garcia-Macia, Marina, Buondelmonte, Costantina, Burmistrova, Olga, Bonora, Nicolo, Alonso-Batan, Paula, Morant-Ferrando, Brenda, Vicente-Gutierrez, Carlos, Jimenez-Blasco, Daniel, Quintana-Cabrera, Ruben, Fernandez, Emilio, Llop, Jordi, Ramos-Cabrer, Pedro, Sharaireh, Aseel, Guevara-Ferrer, Marta, Fitzpatrick, Lorna, Thompton, Christopher D., McKay, Tristan R., Storch, Stephan, Medina, Diego L., Mole, Sara E., Fedichev, Peter O., Almeida, Angeles, Bolaños, Juan P.
Publicado 2022