Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

por Serbulea, Vlad, Upchurch, Clint M., Schappe, Michael S., Voigt, Paxton, DeWeese, Dory E., Desai, Bimal N., Meher, Akshaya K., Leitinger, Norbert
Publicado 2018

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

por Serbulea, Vlad, Upchurch, Clint M., Ahern, Katelyn W., Bories, Gael, Voigt, Paxton, DeWeese, Dory E., Meher, Akshaya K., Harris, Thurl E., Leitinger, Norbert
Publicado 2017

Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibi...

por McCubrey, James A., Meher, Akshaya K., Akula, Shaw M., Abrams, Stephen L., Steelman, Linda S., LaHair, Michelle M., Franklin, Richard A., Martelli, Alberto M., Ratti, Stefano, Cocco, Lucio, Barbaro, Fulvio, Duda, Przemysław, Gizak, Agnieszka
Publicado 2022

GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals

por Abrams, Stephen L., Akula, Shaw M., Meher, Akshaya K., Steelman, Linda S., Gizak, Agnieszka, Duda, Przemysław, Rakus, Dariusz, Martelli, Alberto M., Ratti, Stefano, Cocco, Lucio, Montalto, Giuseppe, Cervello, Melchiorre, Ruvolo, Peter, Libra, Massimo, Falzone, Luca, Candido, Saverio, McCubrey, James A.
Publicado 2021

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

por Adamson, Samantha E., Meher, Akshaya K., Chiu, Yu-hsin, Sandilos, Joanna K., Oberholtzer, Nathaniel P., Walker, Natalie N., Hargett, Stefan R., Seaman, Scott A., Peirce-Cottler, Shayn M., Isakson, Brant E., McNamara, Coleen A., Keller, Susanna R., Harris, Thurl E., Bayliss, Douglas A., Leitinger, Norbert
Publicado 2015

Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels

por Senthivinayagam, Subramanian, Serbulea, Vlad, Upchurch, Clint M., Polanowska-Grabowska, Renata, Mendu, Suresh K., Sahu, Srabani, Jayaguru, Prathiba, Aylor, Kevin W., Chordia, Mahendra D., Steinberg, Limor, Oberholtzer, Nathaniel, Uchiyama, Seichii, Inada, Noriko, Lorenz, Ulrike M., Harris, Thurl E., Keller, Susanna R., Meher, Akshaya K., Kadl, Alexandra, Desai, Bimal N., Kundu, Bijoy K., Leitinger, Norbert
Publicado 2020