Molecular Insights of p47(phox) Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production

por Meijles, Daniel N., Fan, Lampson M., Howlin, Brendan J., Li, Jian-Mei
Publicado 2014

Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling

por Cooper, Susanna T. E., Westaby, Joseph D., Haines, Zoe H. R., Malone, Giles O., Sheppard, Mary N., Meijles, Daniel N.
Publicado 2022

Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury

por El-Rashid, Maryam, Nguyen-Ngo, Danny, Minhas, Nikita, Meijles, Daniel N., Li, Jennifer, Ghimire, Kedar, Julovi, Sohel, Rogers, Natasha M.
Publicado 2020

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α(1)-adrenergic receptors

por Meijles, Daniel N., Fuller, Stephen J., Cull, Joshua J., Alharbi, Hajed O., Cooper, Susanna T.E., Sugden, Peter H., Clerk, Angela
Publicado 2021

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

por Sahoo, Sanghamitra, Meijles, Daniel N., Al Ghouleh, Imad, Tandon, Manuj, Cifuentes-Pagano, Eugenia, Sembrat, John, Rojas, Mauricio, Goncharova, Elena, Pagano, Patrick J.
Publicado 2016

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

por Meijles, Daniel N., Zoumpoulidou, Georgia, Markou, Thomais, Rostron, Kerry A., Patel, Rishi, Lay, Kenneth, Handa, Balvinder S., Wong, Bethany, Sugden, Peter H., Clerk, Angela
Publicado 2019

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

por Fuller, Stephen J., Edmunds, Nick S., McGuffin, Liam J., Hardyman, Michelle A., Cull, Joshua J., Alharbi, Hajed O., Meijles, Daniel N., Sugden, Peter H., Clerk, Angela
Publicado 2021

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

por Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Publicado 2020

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

por Meijles, Daniel N., Cull, Joshua J., Cooper, Susanna T.E., Markou, Thomais, Hardyman, Michelle A., Fuller, Stephen J., Alharbi, Hajed O., Haines, Zoe H.R., Alcantara-Alonso, Viridiana, Glennon, Peter E., Sheppard, Mary N., Sugden, Peter H., Clerk, Angela
Publicado 2021

Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease

por Kumar, Apoorva A., Yeo, Natalie, Whittaker, Max, Attra, Priya, Barrick, Thomas R., Bridges, Leslie R., Dickson, Dennis W., Esiri, Margaret M., Farris, Chad W., Graham, Delyth, Lin, Wen Lang, Meijles, Daniel N., Pereira, Anthony C., Perry, Gregory, Rosene, Douglas L., Shtaya, Anan B., Van Agtmael, Tom, Zamboni, Giovanna, Hainsworth, Atticus H.
Publicado 2022

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

por Marshall, Jacqueline J.T., Cull, Joshua J., Alharbi, Hajed O., Zaw Thin, May, Cooper, Susanna T.E., Barrington, Christopher, Vanyai, Hannah, Snoeks, Thomas, Siow, Bernard, Suáarez-Bonnet, Alejandro, Herbert, Eleanor, Stuckey, Daniel J., Cameron, Angus J.M., Prin, Fabrice, Cook, Andrew C., Priestnall, Simon L., Chotani, Sonia, Rackham, Owen J. L., Meijles, Daniel N., Mohun, Tim, Clerk, Angela, Parker, Peter J.
Publicado 2022

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

por Clerk, Angela, Meijles, Daniel N., Hardyman, Michelle A., Fuller, Stephen J., Chothani, Sonia P., Cull, Joshua J., Cooper, Susanna T.E., Alharbi, Hajed O., Vanezis, Konstantinos, Felkin, Leanne E., Markou, Thomais, Leonard, Samuel J., Shaw, Spencer W., Rackham, Owen J.L., Cook, Stuart A., Glennon, Peter E., Sheppard, Mary N., Sembrat, John C., Rojas, Mauricio, McTiernan, Charles F., Barton, Paul J., Sugden, Peter H.
Publicado 2022