Catechins as Tools to Understand the Molecular Basis of Neurodegeneration

por Martinez Pomier, Karla, Ahmed, Rashik, Melacini, Giuseppe
Publicado 2020

The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

por Selvaratnam, Rajeevan, Mazhab-Jafari, Mohammad T., Das, Rahul, Melacini, Giuseppe
Publicado 2012

Toward a molecular mechanism for the interaction of ATP with alpha-synuclein

por Kamski-Hennekam, Evelyn Rose, Huang, Jinfeng, Ahmed, Rashik, Melacini, Giuseppe
Publicado 2023

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

por Boulton, Stephen, Akimoto, Madoka, Selvaratnam, Rajeevan, Bashiri, Amir, Melacini, Giuseppe
Publicado 2014

Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states

por Byun, Jung Ah, VanSchouwen, Bryan, Akimoto, Madoka, Melacini, Giuseppe
Publicado 2020

Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes

por Ahmed, Rashik, Huang, Jinfeng, Lifshitz, Romi, Martinez Pomier, Karla, Melacini, Giuseppe
Publicado 2021

Divergent allostery reveals critical differences between structurally homologous regulatory domains of Plasmodium falciparum and human protein kinase G

por Byun, Jung Ah, VanSchouwen, Bryan, Huang, Jinfeng, Baryar, Ubaidullah, Melacini, Giuseppe
Publicado 2022

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

por Akimoto, Madoka, McNicholl, Eric Tyler, Ramkissoon, Avinash, Moleschi, Kody, Taylor, Susan S., Melacini, Giuseppe
Publicado 2015

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

por Ahmed, Alveena, Boulton, Stephen, Shao, Hongzhao, Akimoto, Madoka, Natarajan, Amarnath, Cheng, Xiaodong, Melacini, Giuseppe
Publicado 2019

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

por Zhu, Yingmin, Chen, Haijun, Boulton, Stephen, Mei, Fang, Ye, Na, Melacini, Giuseppe, Zhou, Jia, Cheng, Xiaodong
Publicado 2015

State-selective frustration as a key driver of allosteric pluripotency

por Byun, Jung Ah, VanSchouwen, Bryan, Parikh, Nishi, Akimoto, Madoka, McNicholl, Eric Tyler, Melacini, Giuseppe
Publicado 2021

QSAR models reveal new EPAC-selective allosteric modulators

por Mohamed, Hebatallah, Shao, Hongzhao, Akimoto, Madoka, Darveau, Patrick, MacKinnon, Marc R., Magolan, Jakob, Melacini, Giuseppe
Publicado 2022

Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

por Shoaib, Muhammad M., Huynh, Vincent, Shad, Yousuf, Ahmed, Rashik, Jesmer, Alexander H., Melacini, Giuseppe, Wylie, Ryan G.
Publicado 2019

Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division

por Almawi, Ahmad W., Langlois-Lemay, Laurence, Boulton, Stephen, Rodríguez González, Javier, Melacini, Giuseppe, D’Amours, Damien, Guarné, Alba
Publicado 2020

Distance-Based Configurational Entropy of Proteins from Molecular Dynamics Simulations

por Fogolari, Federico, Corazza, Alessandra, Fortuna, Sara, Soler, Miguel Angel, VanSchouwen, Bryan, Brancolini, Giorgia, Corni, Stefano, Melacini, Giuseppe, Esposito, Gennaro
Publicado 2015

‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7

por Almawi, Ahmad W., Matthews, Lindsay A., Larasati, Myrox, Polina, Boulton, Stephen, Lai, Christine, Moraes, Trevor, Melacini, Giuseppe, Ghirlando, Rodolfo, Duncker, Bernard P., Guarné, Alba
Publicado 2016

Atomic resolution map of the soluble amyloid beta assembly toxic surfaces

por Ahmed, Rashik, Akcan, Michael, Khondker, Adree, Rheinstädter, Maikel C., Bozelli, José C., Epand, Richard M., Huynh, Vincent, Wylie, Ryan G., Boulton, Stephen, Huang, Jinfeng, Verschoor, Chris P., Melacini, Giuseppe
Publicado 2019

An auto-inhibited state of protein kinase G and implications for selective activation

por Sharma, Rajesh, Kim, Jeong Joo, Qin, Liying, Henning, Philipp, Akimoto, Madoka, VanSchouwen, Bryan, Kaur, Gundeep, Sankaran, Banumathi, MacKenzie, Kevin R, Melacini, Giuseppe, Casteel, Darren E, Herberg, Friedrich W, Kim, Choel
Publicado 2022

Erythro-VLPs: Anchoring SARS-CoV-2 spike proteins in erythrocyte liposomes

por Himbert, Sebastian, Gastaldo, Isabella Passos, Ahmed, Rashik, Pomier, Karla Martinez, Cowbrough, Braeden, Jahagirdar, Dushyant, Ros, Samantha, Juhasz, Janos, Stöver, Harald D. H., Ortega, Joaquin, Melacini, Giuseppe, Bowdish, Dawn M. E., Rheinstädter, Maikel C.
Publicado 2022

Structures of human PKG reveal cGMP-selectived activation mechanisms

por Huang, Gilbert Y, Kim, Jeong J, Reger, Albert S, Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E, Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W, Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W, Kim, Choel
Publicado 2013