Leveraging systems biology approaches in clinical pharmacology

por Melas, Ioannis N, Kretsos, Kosmas, Alexopoulos, Leonidas G
Publicado 2013

Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs

por Melas, Ioannis N., Samaga, Regina, Alexopoulos, Leonidas G., Klamt, Steffen
Publicado 2013

Network Reconstruction Based on Proteomic Data and Prior Knowledge of Protein Connectivity Using Graph Theory

por Stavrakas, Vassilis, Melas, Ioannis N., Sakellaropoulos, Theodore, Alexopoulos, Leonidas G.
Publicado 2015

Combined logical and data-driven models for linking signalling pathways to cellular response

por Melas, Ioannis N, Mitsos, Alexander, Messinis, Dimitris E, Weiss, Thomas S, Alexopoulos, Leonidas G
Publicado 2011

Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data

por Mitsos, Alexander, Melas, Ioannis N., Siminelakis, Paraskeuas, Chairakaki, Aikaterini D., Saez-Rodriguez, Julio, Alexopoulos, Leonidas G.
Publicado 2009

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

por Mitsos, Alexander, Melas, Ioannis N., Morris, Melody K., Saez-Rodriguez, Julio, Lauffenburger, Douglas A., Alexopoulos, Leonidas G.
Publicado 2012

Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy

por Messinis, Dimitris E., Melas, Ioannis N., Hur, Junguk, Varshney, Navya, Alexopoulos, Leonidas G., Bai, Jane P.F.
Publicado 2018

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

por Wang, Yan, Lloyd, Katy A., Melas, Ioannis, Zhou, Diana, Thyagarajan, Radha, Lindqvist, Joakim, Hansson, Monika, Svärd, Anna, Mathsson-Alm, Linda, Kastbom, Alf, Lundberg, Karin, Klareskog, Lars, Catrina, Anca I., Rapecki, Stephen, Malmström, Vivianne, Grönwall, Caroline
Publicado 2019

A crowd-sourcing approach for the construction of species-specific cell signaling networks

por Bilal, Erhan, Sakellaropoulos, Theodore, Participants, Challenge, Melas, Ioannis N., Messinis, Dimitris E., Belcastro, Vincenzo, Rhrissorrakrai, Kahn, Meyer, Pablo, Norel, Raquel, Iskandar, Anita, Blaese, Elise, Rice, John J., Peitsch, Manuel C., Hoeng, Julia, Stolovitzky, Gustavo, Alexopoulos, Leonidas G., Poussin, Carine
Publicado 2015

The species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells

por Poussin, Carine, Mathis, Carole, Alexopoulos, Leonidas G, Messinis, Dimitris E, Dulize, Rémi H J, Belcastro, Vincenzo, Melas, Ioannis N, Sakellaropoulos, Theodore, Rhrissorrakrai, Kahn, Bilal, Erhan, Meyer, Pablo, Talikka, Marja, Boué, Stéphanie, Norel, Raquel, Rice, John J, Stolovitzky, Gustavo, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia
Publicado 2014