A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)

por Yan, Yan, Gu, Xin, Xu, H. Eric, Melcher, Karsten
Publicado 2017

Defining the minimum substrate and charge recognition model of gamma-secretase

por Yan, Yan, Xu, Ting-Hai, Melcher, Karsten, Xu, H Eric
Publicado 2017

Structure and Physiological Regulation of AMPK

por Yan, Yan, Zhou, X. Edward, Xu, H. Eric, Melcher, Karsten
Publicado 2018

Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

por Wu, Zhong-shan, Cheng, Hao, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado 2015

Androgen receptor: structure, role in prostate cancer and drug discovery

por Tan, MH Eileen, Li, Jun, Xu, H Eric, Melcher, Karsten, Yong, Eu-leong
Publicado 2015

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

por Xu, Ting-Hai, Yan, Yan, Kang, Yanyong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado 2016

H(2)O(2) Inhibits ABA-Signaling Protein Phosphatase HAB1

por Sridharamurthy, Madhuri, Kovach, Amanda, Zhao, Yang, Zhu, Jian-Kang, Xu, H. Eric, Swaminathan, Kunchithapadam, Melcher, Karsten
Publicado 2014

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

por Yan, Yan, Xu, Ting-Hai, Harikumar, Kaleeckal G., Miller, Laurence J., Melcher, Karsten, Xu, H. Eric
Publicado 2017

Abscisic Acid Signaling: Thermal Stability Shift Assays as Tool to Analyze Hormone Perception and Signal Transduction

por Soon, Fen-Fen, Suino-Powell, Kelly M., Li, Jun, Yong, Eu-Leong, Xu, H. Eric, Melcher, Karsten
Publicado 2012

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

por Ke, Jiyuan, Ma, Honglei, Gu, Xin, Thelen, Adam, Brunzelle, Joseph S., Li, Jiayang, Xu, H. Eric, Melcher, Karsten
Publicado 2015

Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro

por Yi, Wei, Shi, Jingjing, Zhao, Guanguan, Zhou, X. Edward, Suino-Powell, Kelly, Melcher, Karsten, Xu, H. Eric
Publicado 2017

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

por Sasi, Nanda Kumar, Tiwari, Kanchan, Soon, Fen-Fen, Bonte, Dorine, Wang, Tong, Melcher, Karsten, Xu, H. Eric, Weinreich, Michael
Publicado 2014

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

por de Waal, Parker W., Shi, Jingjing, You, Erli, Wang, Xiaoxi, Melcher, Karsten, Jiang, Yi, Xu, H. Eric, Dickson, Bradley M.
Publicado 2020

Structure of DNA methyltransferases DNMT3A/DNMT3B bound to a nucleosome

por Xu, Ting-Hai, Liu, Minmin, Zhou, X. Edward, Liang, Gangning, Zhao, Gongpu, Xu, H. Eric, Melcher, Karsten, Jones, Peter A.
Publicado 2020

Structural basis for corepressor assembly by the orphan nuclear receptor TLX

por Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Searose-Xu, Kelvin, Zhang, Chun-Li, Tsai, Chih-Cheng, Melcher, Karsten, Xu, H. Eric
Publicado 2015

An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain

por Yin, Yanting, Zhou, X Edward, Hou, Li, Zhao, Li-Hua, Liu, Bo, Wang, Gaihong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado 2016

The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation

por Tan, M. H. Eileen, Zhou, X. Edward, Soon, Fen-Fen, Li, Xiaodan, Li, Jun, Yong, Eu-Leong, Melcher, Karsten, Xu, H. Eric
Publicado 2013

Structural basis of Fusarium myosin I inhibition by phenamacril

por Zhou, Yuxin, Zhou, X. Edward, Gong, Yuanping, Zhu, Yuanye, Cao, Xiaoman, Brunzelle, Joseph S., Xu, H. Eric, Zhou, Mingguo, Melcher, Karsten, Zhang, Feng
Publicado 2020

Molecular assembly of rhodopsin with G protein-coupled receptor kinases

por He, Yuanzheng, Gao, Xiang, Goswami, Devrishi, Hou, Li, Pal, Kuntal, Yin, Yanting, Zhao, Gongpu, Ernst, Oliver P, Griffin, Patrick, Melcher, Karsten, Xu, H Eric
Publicado 2017

Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R

por Zhou, X. Edward, Schultz, Chad R., Suino Powell, Kelly, Henrickson, Amy, Lamp, Jared, Brunzelle, Joseph S., Demeler, Borries, Vega, Irving E., Bachmann, André S., Melcher, Karsten
Publicado 2022