Bioequivalence of Two Intravenous Artesunate Products with Its Active Metabolite Following Single and Multiple Injections

por Li, Qigui, Xie, Lisa, Melendez, Victor, Weina, Peter
Publicado 2011

The Coincidental Evolution of Virulence Partially Explains the Virulence in a Generalist Entomopathogenic

por Trejo-Meléndez, Víctor José, Méndez-López, Texca T., Contreras-Garduño, Jorge
Publicado 2023

Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

por Wang, Hongxing, Li, Qigui, Reyes, Sean, Zhang, Jing, Xie, Lisa, Melendez, Victor, Hickman, Mark, Kozar, Michael P.
Publicado 2013

Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections

por Li, Qigui, O’Neil, Michael, Xie, Lisa, Caridha, Diana, Zeng, Qiang, Zhang, Jing, Pybus, Brandon, Hickman, Mark, Melendez, Victor
Publicado 2014

Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model

por Fracisco, Susan, Teja-isavadharm, Paktiya, Gettayacamin, Montip, Berman, Jonathan, Li, Qigui, Melendez, Victor, Saunders, David, Xie, Lisa, Ohrt, Colin
Publicado 2014

Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study

por Miller, Robert Scott, Li, Qigui, Cantilena, Louis R, Leary, Kevin J, Saviolakis, George A, Melendez, Victor, Smith, Bryan, Weina, Peter J
Publicado 2012

Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study

por Li, Qigui, Remich, Shon, Miller, Scott R, Ogutu, Bernhards, Otieno, Walter, Melendez, Victor, Teja-Isavadharm, Paktiya, Weina, Peter J, Hickman, Mark R, Smith, Bryan, Polhemus, Mark
Publicado 2014

A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

por Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Siripokasupkul, Raveewan, Apinan, Roongnapa, Chanarat, Nitima, Lim, Apassorn, Wannaying, Srisombat, Saunders, David, Fukuda, Mark M., Miller, Robert S., Weina, Peter J., Meléndez, Victor
Publicado 2010

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

por Milner, Erin, McCalmont, William, Bhonsle, Jayendra, Caridha, Diana, Cobar, Jose, Gardner, Sean, Gerena, Lucia, Goodine, Duane, Lanteri, Charlotte, Melendez, Victor, Roncal, Norma, Sousa, Jason, Wipf, Peter, Dow, Geoffrey Stuart
Publicado 2010

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

por Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S
Publicado 2013

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

por Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publicado 2013

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

por Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publicado 2012

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

por Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Nanayakkara, N P Dhammika, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S
Publicado 2014