Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance

por This, Sébastien, Valbon, Stefanie F., Lebel, Marie-Ève, Melichar, Heather J.
Publicado 2021

Conserved and divergent aspects of human T-cell development and migration in humanized mice

por Halkias, Joanna, Yen, Bonnie, Taylor, Kayleigh T, Reinhartz, Olaf, Winoto, Astar, Robey, Ellen A, Melichar, Heather J
Publicado 2015

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

por Lebel, Marie-Ève, Coutelier, Marie, Galipeau, Maria, Kleinman, Claudia L., Moon, James J., Melichar, Heather J.
Publicado 2020

The ICOS–ICOSL pathway tunes thymic selection

por Dong, Mengqi, Chang, Jinsam, Lebel, Marie‐Ève, Gervais, Noémie, Fournier, Marilaine, Mallet Gauthier, Ève, Suh, Woong‐Kyung, Melichar, Heather J
Publicado 2022

Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity

por Lombard-Vadnais, Félix, Chabot-Roy, Geneviève, Zahn, Astrid, Rodriguez Torres, Sahily, Di Noia, Javier M., Melichar, Heather J., Lesage, Sylvie
Publicado 2022

Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development

por Au-Yeung, Byron B., Melichar, Heather J., Ross, Jenny O., Cheng, Debra A., Zikherman, Julie, Shokat, Kevan M., Robey, Ellen A., Weiss, Arthur
Publicado 2014

Internalization and TLR-dependent type I interferon production by Inflammatory monocytes to Toxoplasma gondii

por Han, Seong-Ji, Melichar, Heather J., Coombes, Janine L., Chan, Shiao Wei, Koshy, Anita A., Boothroyd, John C., Barton, Gregory M., Robey, Ellen A.
Publicado 2014

CD5 levels define functionally heterogeneous populations of naïve human CD4(+) T cells

por Sood, Aditi, Lebel, Marie‐Ève, Dong, Mengqi, Fournier, Marilaine, Vobecky, Suzanne J., Haddad, Élie, Delisle, Jean‐Sébastien, Mandl, Judith N., Vrisekoop, Nienke, Melichar, Heather J.
Publicado 2021

p16(INK4a) Regulates Cellular Senescence in PD-1-Expressing Human T Cells

por Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J., Mallette, Frédérick A., Delisle, Jean-Sébastien
Publicado 2021

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life

por Hata, Masayuki, Hata, Maki, Andriessen, Elisabeth M.M.A., Juneau, Rachel, Pilon, Frédérique, Crespo-Garcia, Sergio, Diaz-Marin, Roberto, Guber, Vera, Binet, Francois, Fournier, Frédérik, Buscarlet, Manuel, Grou, Caroline, Calderon, Virginie, Heckel, Emilie, Melichar, Heather J., Joyal, Jean-Sebastien, Wilson, Ariel M., Sapieha, Przemyslaw
Publicado 2023