Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening

por Arenaz-Callao, María Pilar, González del Río, Rubén, Lucía Quintana, Ainhoa, Thompson, Charles J., Mendoza-Losana, Alfonso, Ramón-García, Santiago
Publicado 2019

New molecular settings to support in vivo anti-malarial assays

por Bahamontes-Rosa, Noemí, Alejandre, Ane Rodriguez, Gomez, Vanesa, Viera, Sara, Gomez-Lorenzo, María G., Sanz-Alonso, Laura María, Mendoza-Losana, Alfonso
Publicado 2016

Repurposing clinically approved cephalosporins for tuberculosis therapy

por Ramón-García, Santiago, González del Río, Rubén, Villarejo, Angel Santos, Sweet, Gaye D., Cunningham, Fraser, Barros, David, Ballell, Lluís, Mendoza-Losana, Alfonso, Ferrer-Bazaga, Santiago, Thompson, Charles J.
Publicado 2016

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

por Grover, Shipra, Engelhart, Curtis A., Pérez-Herrán, Esther, Li, Wei, Abrahams, Katherine A., Papavinasasundaram, Kadamba, Bean, James M., Sassetti, Christopher M., Mendoza-Losana, Alfonso, Besra, Gurdyal S., Jackson, Mary, Schnappinger, Dirk
Publicado 2020

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach

por Soto, Ramón, Perez-Herran, Esther, Rodriguez, Beatriz, Duma, Bogdan M., Cacho-Izquierdo, Monica, Mendoza-Losana, Alfonso, Lelievre, Joel, Aguirre, David Barros, Ballell, Lluis, Cox, Liam R., Alderwick, Luke J., Besra, Gurdyal S.
Publicado 2018

First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment

por Tenero, David, Derimanov, Geo, Carlton, Alex, Tonkyn, John, Davies, Matt, Cozens, Simon, Gresham, Stephanie, Gaudion, Alison, Puri, Adeep, Muliaditan, Morris, Rullas-Trincado, Joaquin, Mendoza-Losana, Alfonso, Skingsley, Andrew, Barros-Aguirre, David
Publicado 2019

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis

por Tsui, Clement K. M., Sorrentino, Flavia, Narula, Gagandeep, Mendoza-Losana, Alfonso, del Rio, Ruben Gonzalez, Herrán, Esther Pérez, Lopez, Abraham, Bojang, Adama, Zheng, Xingji, Remuiñán-Blanco, Modesto Jesus, Av-Gay, Yossef
Publicado 2022

Functional screening of selective mitochondrial inhibitors of Plasmodium

por Gomez-Lorenzo, Maria G., Rodríguez-Alejandre, Ane, Moliner-Cubel, Sonia, Martínez-Hoyos, María, Bahamontes-Rosa, Noemí, Gonzalez del Rio, Rubén, Ródenas, Carolina, Fuente, Jesús de la, Lavandera, Jose Luis, García-Bustos, Jose F., Mendoza-Losana, Alfonso
Publicado 2018

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1

por Richter, Adrian, Rudolph, Ines, Möllmann, Ute, Voigt, Kerstin, Chung, Chun-wa, Singh, Onkar M. P., Rees, Michael, Mendoza-Losana, Alfonso, Bates, Robert, Ballell, Lluís, Batt, Sarah, Veerapen, Natacha, Fütterer, Klaus, Besra, Gurdyal, Imming, Peter, Argyrou, Argyrides
Publicado 2018

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

por Prati, Federica, Zuccotto, Fabio, Fletcher, Daniel, Convery, Maire A., Fernandez‐Menendez, Raquel, Bates, Robert, Encinas, Lourdes, Zeng, Jingkun, Chung, Chun‐wa, De Dios Anton, Paco, Mendoza‐Losana, Alfonso, Mackenzie, Claire, Green, Simon R., Huggett, Margaret, Barros, David, Wyatt, Paul G., Ray, Peter C.
Publicado 2018

Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

por Dutta, Noton K., Klinkenberg, Lee G., Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S., Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C.
Publicado 2019

Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease...

por Johnson, Roch Christian, Sáez-López, Emma, Anagonou, Esaï Sèdjro, Kpoton, Godwin Gérard, Ayelo, Adjimon Gilbert, Gnimavo, Ronald Sètondji, Mignanwande, Franck Zinsou, Houezo, Jean-Gabin, Sopoh, Ghislain Emmanuel, Addo, Juliet, Orford, Lindsay, Vlasakakis, Georgios, Biswas, Nandita, Calderon, Felix, Della Pasqua, Oscar, Gine-March, Anna, Herrador, Zaida, Mendoza-Losana, Alfonso, Díez, Gabriel, Cruz, Israel, Ramón-García, Santiago
Publicado 2022

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

por Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J., Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H., Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R., Alvarez-Ruiz, Emilio, Marti-Renom, Marc A., Overington, John P., Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David
Publicado 2015

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tub...

por Remuiñán, Modesto J., Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J., Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Minick, Douglas J., Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S., Ballell, Lluís, Cammack, Nicholas
Publicado 2013

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

por Martínez-Hoyos, María, Perez-Herran, Esther, Gulten, Gulcin, Encinas, Lourdes, Álvarez-Gómez, Daniel, Alvarez, Emilio, Ferrer-Bazaga, Santiago, García-Pérez, Adolfo, Ortega, Fátima, Angulo-Barturen, Iñigo, Rullas-Trincado, Joaquin, Blanco Ruano, Delia, Torres, Pedro, Castañeda, Pablo, Huss, Sophie, Fernández Menéndez, Raquel, González del Valle, Silvia, Ballell, Lluis, Barros, David, Modha, Sundip, Dhar, Neeraj, Signorino-Gelo, François, McKinney, John D., García-Bustos, Jose Francisco, Lavandera, Jose Luis, Sacchettini, James C., Jimenez, M. Soledad, Martín-Casabona, Nuria, Castro-Pichel, Julia, Mendoza-Losana, Alfonso
Publicado 2016

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

por Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Toh, May Fern, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas
Publicado 2017

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

por Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas
Publicado 2018