PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

por Takita, Hiroyuki, Barnett, Shelby, Zhang, Yueping, Ménochet, Karelle, Shen, Hong, Ogungbenro, Kayode, Galetin, Aleksandra
Publicado 2021

Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B‐Mediated Drug–Drug Interactions Using Population Pharmacokinetic Modeling and Simulation

por Barnett, Shelby, Ogungbenro, Kayode, Ménochet, Karelle, Shen, Hong, Lai, Yurong, Humphreys, W. Griffith, Galetin, Aleksandra
Publicado 2018

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

por Ménochet, Karelle, Yu, Hongbin, Wang, Bonnie, Tibbitts, Jay, Hsu, Cheng-Pang, Kamath, Amrita V., Richter, Wolfgang F., Baumann, Andreas
Publicado 2022

TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life

por Davé, Emma, Durrant, Oliver, Dhami, Neha, Compson, Joanne, Broadbridge, Janice, Archer, Sophie, Maroof, Asher, Whale, Kevin, Menochet, Karelle, Bonnaillie, Pierre, Barry, Emily, Wild, Gavin, Peerboom, Claude, Bhatta, Pallavi, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Heywood, Sam P.
Publicado 2023

Serum albumin binding knob domains engineered within a V(H) framework III bispecific antibody format and as chimeric peptides

por Adams, Ralph, Joyce, Callum, Kuravskiy, Mikhail, Harrison, Katriona, Ahdash, Zainab, Balmforth, Matthew, Chia, Kelda, Marceddu, Cinzia, Coates, Matthew, Snowden, James, Goursaud, Emmanuel, Ménochet, Karelle, van den Elsen, Jean, Payne, Richard J., Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex
Publicado 2023