The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities

por Mercader, Josep M., Florez, Jose C.
Publicado 2017

Adaptation to environmental factors shapes the organization of regulatory regions in microbial communities

por Fernandez, Leyden, Mercader, Josep M, Planas-Fèlix, Mercè, Torrents, David
Publicado 2014

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis

por Leong, Aaron, Cole, Joanne B., Brenner, Laura N., Meigs, James B., Florez, Jose C., Mercader, Josep M.
Publicado 2021

Analysis of Glucocorticoid-Related Genes Reveal CCHCR1 as a New Candidate Gene for Type 2 Diabetes

por Brenner, Laura N, Mercader, Josep M, Robertson, Catherine C, Cole, Joanne, Chen, Ling, Jacobs, Suzanne B R, Rich, Stephen S, Florez, Jose C
Publicado 2020

Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes

por Deutsch, Aaron J., Schroeder, Philip H., Mandla, Ravi, Kang, Sarah, Erenler, Feyza, Mercader, Josep M., Udler, Miriam S., Florez, Jose C., Brenner, Laura N.
Publicado 2023

Algorithms for the identification of prevalent diabetes in the All of Us Research Program validated using polygenic scores – a new resource for diabetes precision medicine

por Szczerbinski, Lukasz, Mandla, Ravi, Schroeder, Philip, Porneala, Bianca C., Li, Josephine H., Florez, Jose C., Mercader, Josep M., Manning, Alisa K., Udler, Miriam S.
Publicado 2023

Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain

por Geidenstam, Nina, Hsu, Yu-Han H., Astley, Christina M., Mercader, Josep M., Ridderstråle, Martin, Gonzalez, Maria E., Gonzalez, Clicerio, Hirschhorn, Joel N., Salem, Rany M.
Publicado 2019

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

por Sadler, Jessica B. A., Wenzel, Dawn M., Strohacker, Lauren K., Guindo-Martínez, Marta, Alam, Steven L., Mercader, Josep M., Torrents, David, Ullman, Katharine S., Sundquist, Wesley I., Martin-Serrano, Juan
Publicado 2018

A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma

por Chinnaswamy, Sreedhar, Wardzynska, Aleksandra, Pawelczyk, Malgorzata, Makowska, Joanna, Skaaby, Tea, Mercader, Josep M., Ahluwalia, Tarunveer S., Grarup, Niels, Guindo-Martinez, Marta, Bisgaard, Hans, Torrents, David, Linneberg, Allan, Bønnelykke, Klaus, Kowalski, Marek L.
Publicado 2017

PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data

por Hsu, Yu-Han H., Churchhouse, Claire, Pers, Tune H., Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.
Publicado 2019

Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19

por Schroeder, Philip H., Brenner, Laura N., Kaur, Varinderpal, Cromer, Sara J., Armstrong, Katrina, LaRocque, Regina C., Ryan, Edward T., Meigs, James B., Florez, Jose C., Charles, Richelle C., Mercader, Josep M., Leong, Aaron
Publicado 2022

Common Genetic Variants of Surfactant Protein-D (SP-D) Are Associated with Type 2 Diabetes

por Pueyo, Neus, Ortega, Francisco J., Mercader, Josep M., Moreno-Navarrete, José M., Sabater, Monica, Bonàs, Sílvia, Botas, Patricia, Delgado, Elías, Ricart, Wifredo, Martinez-Larrad, María T., Serrano-Ríos, Manuel, Torrents, David, Fernández-Real, José M.
Publicado 2013

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

por Hsu, Yu-Han H., Astley, Christina M., Cole, Joanne B., Vedantam, Sailaja, Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.
Publicado 2020

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

por Udler, Miriam S., Kim, Jaegil, von Grotthuss, Marcin, Bonàs-Guarch, Sílvia, Cole, Joanne B., Chiou, Joshua, Boehnke, Michael, Laakso, Markku, Atzmon, Gil, Glaser, Benjamin, Mercader, Josep M., Gaulton, Kyle, Flannick, Jason, Getz, Gad, Florez, Jose C.
Publicado 2018

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems

por Mercader, Josep M., Puiggros, Montserrat, Segrè, Ayellet V., Planet, Evarist, Sorianello, Eleonora, Sebastian, David, Rodriguez-Cuenca, Sergio, Ribas, Vicent, Bonàs-Guarch, Sílvia, Draghici, Sorin, Yang, Chenjing, Mora, Sílvia, Vidal-Puig, Antoni, Dupuis, Josée, Florez, Jose C., Zorzano, Antonio, Torrents, David
Publicado 2012

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors

por Merino, Jordi, Jablonski, Kathleen A., Mercader, Josep M., Kahn, Steven E., Chen, Ling, Harden, Maegan, Delahanty, Linda M., Araneta, Maria Rosario G., Walford, Geoffrey A., Jacobs, Suzanne B.R., Ibebuogu, Uzoma N., Franks, Paul W., Knowler, William C., Florez, Jose C.
Publicado 2020

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium

por Srinivasan, Shylaja, Chen, Ling, Todd, Jennifer, Divers, Jasmin, Gidding, Samuel, Chernausek, Steven, Gubitosi-Klug, Rose A., Kelsey, Megan M., Shah, Rachana, Black, Mary Helen, Wagenknecht, Lynne E., Manning, Alisa, Flannick, Jason, Imperatore, Giuseppina, Mercader, Josep M., Dabelea, Dana, Florez, Jose C.
Publicado 2021

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

por Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Publicado 2023

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

por Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Publicado 2023

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes

por Schroeder, Philip, Mandla, Ravi, Huerta-Chagoya, Alicia, Alkanak, Ahmed, Nagy, Dorka, Szczerbinski, Lukasz, Madsen, Jesper G.S., Cole, Joanne B., Porneala, Bianca, Westerman, Kenneth, Li, Josephine H., Pollin, Toni I., Florez, Jose C., Gloyn, Anna L., Cebola, Inês, Manning, Alisa, Leong, Aaron, Udler, Miriam, Mercader, Josep M.
Publicado 2023