Identification and characterization of human nucleus pulposus cell specific serotypes of adeno-associated virus for gene therapeutic approaches of intervertebral disc disorders

por Mern, Demissew S., Thomé, Claudius
Publicado 2015

Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus ce...

por Shenegelegn Mern, Demissew, Tschugg, Anja, Hartmann, Sebastian, Thomé, Claudius
Publicado 2017

A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identificati...

por Mern, Demissew S., Fontana, Johann, Beierfuß, Anja, Thomé, Claudius, Hegewald, Aldemar A.
Publicado 2013

Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic T...

por Mern, Demissew S., Beierfuß, Anja, Fontana, Johann, Thomé, Claudius, Hegewald, Aldemar A.
Publicado 2014

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix

por Beierfuß, Anja, Hunjadi, Monika, Ritsch, Andreas, Kremser, Christian, Thomé, Claudius, Mern, Demissew Shenegelegn
Publicado 2019

Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells

por Manthey, Carolin, Mern, Demissew S, Gutmann, Anja, Zielinski, Anne J, Herz, Corinna, Lassmann, Silke, Hasskarl, Jens
Publicado 2010

Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders

por Beierfuß, Anja, Dietrich, Hermann, Kremser, Christian, Hunjadi, Monika, Ritsch, Andreas, Rülicke, Thomas, Thomé, Claudius, Mern, Demissew Shenegelegn
Publicado 2017