Next‐generation disease modeling with direct conversion: a new path to old neurons

por Traxler, Larissa, Edenhofer, Frank, Mertens, Jerome
Publicado 2019

Take the shortcut – direct conversion of somatic cells into induced neural stem cells and their biomedical applications

por Erharter, Anita, Rizzi, Sandra, Mertens, Jerome, Edenhofer, Frank
Publicado 2019

Metabolism navigates neural cell fate in development, aging and neurodegeneration

por Traxler, Larissa, Lagerwall, Jessica, Eichhorner, Sophie, Stefanoni, Davide, D'Alessandro, Angelo, Mertens, Jerome
Publicado 2021

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

por Castillo Bautista, Cristina Marisol, Eismann, Kristin, Gentzel, Marc, Pelucchi, Silvia, Mertens, Jerome, Walters, Hannah E., Yun, Maximina H., Sterneckert, Jared
Publicado 2023

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

por Zheng, Xinde, Boyer, Leah, Jin, Mingji, Mertens, Jerome, Kim, Yongsung, Ma, Li, Ma, Li, Hamm, Michael, Gage, Fred H, Hunter, Tony
Publicado 2016

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

por Herdy, Joseph, Schafer, Simon, Kim, Yongsung, Ansari, Zoya, Zangwill, Dina, Ku, Manching, Paquola, Apua, Lee, Hyungjun, Mertens, Jerome, Gage, Fred H
Publicado 2019

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

por Soni, Abhinav, Klütsch, Diana, Hu, Xin, Houtman, Judith, Rund, Nicole, McCloskey, Asako, Mertens, Jerome, Schafer, Simon T., Amin, Hayder, Toda, Tomohisa
Publicado 2021

APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation

por Mertens, Jerome, Stüber, Kathrin, Wunderlich, Patrick, Ladewig, Julia, Kesavan, Jaideep C., Vandenberghe, Rik, Vandenbulcke, Mathieu, van Damme, Philip, Walter, Jochen, Brüstle, Oliver, Koch, Philipp
Publicado 2013

Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons

por van den Hurk, Mark, Lau, Shong, Marchetto, Maria C., Mertens, Jerome, Stern, Shani, Corti, Olga, Brice, Alexis, Winner, Beate, Winkler, Jürgen, Gage, Fred H., Bardy, Cedric
Publicado 2022

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

por Böhnke, Lena, Zhou-Yang, Lucia, Pelucchi, Silvia, Kogler, Flora, Frantal, Daniela, Schön, Florian, Lagerström, Stina, Borgogno, Oliver, Baltazar, Jennifer, Herdy, Joseph R., Kittel-Schneider, Sarah, Defrancesco, Michaela, Mertens, Jerome
Publicado 2022

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71

por Mitschka, Sibylle, Ulas, Thomas, Goller, Tobias, Schneider, Karin, Egert, Angela, Mertens, Jérôme, Brüstle, Oliver, Schorle, Hubert, Beyer, Marc, Klee, Kathrin, Xue, Jia, Günther, Patrick, Bassler, Kevin, Schultze, Joachim L., Kolanus, Waldemar
Publicado 2015

Modifiers of C9orf72 DPR toxicity implicate nucleocytoplasmic transport impairments in c9FTD/ALS

por Jovičić, Ana, Mertens, Jerome, Boeynaems, Steven, Bogaert, Elke, Chai, Noori, Yamada, Shizuka B., Paul, Joseph W., Sun, Shuying, Herdy, Joseph R., Bieri, Gregor, Kramer, Nicholas J., Gage, Fred H., Den Bosch, Ludo Van, Robberecht, Wim, Gitler, Aaron D.
Publicado 2015

Pathological priming causes developmental gene network heterochronicity in autism patient-derived neurons

por Schafer, Simon T., Paquola, Apua C.M., Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J.M., Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N., Marchetto, Maria C., Glass, Christopher K., Mertens, Jerome, Gage, Fred H.
Publicado 2019

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

por Traxler, Larissa, Herdy, Joseph R., Stefanoni, Davide, Eichhorner, Sophie, Pelucchi, Silvia, Szücs, Attila, Santagostino, Alice, Kim, Yongsung, Agarwal, Ravi K., Schlachetzki, Johannes C.M., Glass, Christopher K., Lagerwall, Jessica, Galasko, Douglas, Gage, Fred H., D’Alessandro, Angelo, Mertens, Jerome
Publicado 2022

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

por Mertens, Jerome, Herdy, Joseph R., Traxler, Larissa, Schafer, Simon T., Schlachetzki, Johannes C.M., Böhnke, Lena, Reid, Dylan A., Lee, Hyungjun, Zangwill, Dina, Fernandes, Diana P., Agarwal, Ravi K., Lucciola, Raffaella, Zhou-Yang, Lucia, Karbacher, Lukas, Edenhofer, Frank, Stern, Shani, Horvath, Steve, Paquola, Apua C.M., Glass, Christopher K., Yuan, Shauna H., Ku, Manching, Szücs, Attila, Goldstein, Lawrence S.B., Galasko, Douglas, Gage, Fred H.
Publicado 2021

The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample

por Oedegaard, Ketil J., Alda, Martin, Anand, Anit, Andreassen, Ole A., Balaraman, Yokesh, Berrettini, Wade H., Bhattacharjee, Abesh, Brennand, Kristen J., Burdick, Katherine E., Calabrese, Joseph R., Calkin, Cynthia V., Claasen, Ana, Coryell, William H., Craig, David, DeModena, Anna, Frye, Mark, Gage, Fred H., Gao, Keming, Garnham, Julie, Gershon, Elliot, Jakobsen, Petter, Leckband, Susan G., McCarthy, Michael J., McInnis, Melvin G., Maihofer, Adam X., Mertens, Jerome, Morken, Gunnar, Nievergelt, Caroline M., Nurnberger, John, Pham, Son, Schoeyen, Helle, Shekhtman, Tatyana, Shilling, Paul D., Szelinger, Szabolcs, Tarwater, Bruce, Yao, Jun, Zandi, Peter P., Kelsoe, John R.
Publicado 2016