Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

por Prestigiacomo, Vincenzo, Weston, Anna, Messner, Simon, Lampart, Franziska, Suter-Dick, Laura
Publicado 2017

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

por Altmeyer, Matthias, Messner, Simon, Hassa, Paul O., Fey, Monika, Hottiger, Michael O.
Publicado 2009

Differential basolateral–apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

por Fruhwürth, Stefanie, Kovacs, Werner J., Bittman, Robert, Messner, Simon, Röhrl, Clemens, Stangl, Herbert
Publicado 2014

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

por Hendriks, Delilah F. G., Fredriksson Puigvert, Lisa, Messner, Simon, Mortiz, Wolfgang, Ingelman-Sundberg, Magnus
Publicado 2016

Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins

por Messner, Simon, Leitner, Stephan, Bommassar, Christian, Golderer, Georg, Gröbner, Peter, Werner, Ernst R., Werner-Felmayer, Gabriele
Publicado 2009

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

por Schoeler, Katia, Aufschnaiter, Andreas, Messner, Simon, Derudder, Emmanuel, Herzog, Sebastian, Villunger, Andreas, Rajewsky, Klaus, Labi, Verena
Publicado 2019

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

por Kermanizadeh, Ali, Løhr, Mille, Roursgaard, Martin, Messner, Simon, Gunness, Patrina, Kelm, Jens M, Møller, Peter, Stone, Vicki, Loft, Steffen
Publicado 2014

PARP1 ADP-ribosylates lysine residues of the core histone tails

por Messner, Simon, Altmeyer, Matthias, Zhao, Hongtao, Pozivil, Andrea, Roschitzki, Bernd, Gehrig, Peter, Rutishauser, Dorothea, Huang, Danzhi, Caflisch, Amedeo, Hottiger, Michael O.
Publicado 2010

Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

por Messner, Simon, Fredriksson, Lisa, Lauschke, Volker M., Roessger, Katrin, Escher, Claudia, Bober, Magdalena, Kelm, Jens M., Ingelman-Sundberg, Magnus, Moritz, Wolfgang
Publicado 2018

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

por Bruderer, Roland, Bernhardt, Oliver M., Gandhi, Tejas, Miladinović, Saša M., Cheng, Lin-Yang, Messner, Simon, Ehrenberger, Tobias, Zanotelli, Vito, Butscheid, Yulia, Escher, Claudia, Vitek, Olga, Rinner, Oliver, Reiter, Lukas
Publicado 2015

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

por Proctor, William R., Foster, Alison J., Vogt, Jennifer, Summers, Claire, Middleton, Brian, Pilling, Mark A., Shienson, Daniel, Kijanska, Monika, Ströbel, Simon, Kelm, Jens M., Morgan, Paul, Messner, Simon, Williams, Dominic
Publicado 2017

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

por Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Publicado 2018

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

por Ghosh, Himanish, Auguadri, Luca, Battaglia, Sereina, Simone Thirouin, Zahra, Zemoura, Khaled, Messner, Simon, Acuña, Mario A., Wildner, Hendrik, Yévenes, Gonzalo E., Dieter, Andrea, Kawasaki, Hiroshi, O. Hottiger, Michael, Zeilhofer, Hanns Ulrich, Fritschy, Jean-Marc, Tyagarajan, Shiva K.
Publicado 2016

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of...

por Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.
Publicado 2013