High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

por Brentville, Victoria A., Metheringham, Rachael L., Gunn, Barbara, Durrant, Lindy G.
Publicado 2012

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Respon...

por Symonds, Peter, Marcu, Ana, Cook, Katherine W., Metheringham, Rachael L., Durrant, Lindy G., Brentville, Victoria A.
Publicado 2021

SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

por Xue, Wei, Brentville, Victoria A., Symonds, Peter, Cook, Katherine W., Yagita, Hideo, Metheringham, Rachael L., Durrant, Lindy G.
Publicado 2016

Citrullinated α-enolase is an effective target for anti-cancer immunity

por Cook, Katherine, Daniels, Ian, Symonds, Peter, Pitt, Tracy, Gijon, Mohamed, Xue, Wei, Metheringham, Rachael, Durrant, Lindy, Brentville, Victoria
Publicado 2017

SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade

por Xue, Wei, Metheringham, Rachael L., Brentville, Victoria A., Gunn, Barbara, Symonds, Peter, Yagita, Hideo, Ramage, Judith M., Durrant, Lindy G.
Publicado 2016

A Novel HAGE/WT1-ImmunoBody(®) Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone

por Almshayakhchi, Rukaia, Nagarajan, Divya, Vadakekolathu, Jayakumar, Guinn, Barbara-Ann, Reeder, Stephen, Brentville, Victoria, Metheringham, Rachael, Pockley, A. Graham, Durrant, Lindy, McArdle, Stephanie
Publicado 2021

PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

por Choudhury, Ruhul H, Symonds, Peter, Paston, Samantha J, Daniels, Ian, Cook, Katherine W, Gijon, Mohamed, Metheringham, Rachael L, Brentville, Victoria A, Durrant, Lindy G
Publicado 2022

T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumou...

por Brentville, Victoria A, Symonds, Peter, Cook, Katherine W, Daniels, Ian, Pitt, Tracy, Gijon, Mohamed, Vaghela, Poonam, Xue, Wei, Shah, Sabaria, Metheringham, Rachael L, Durrant, Lindy G
Publicado 2019

Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity

por Cook, Katherine, Xue, Wei, Atabani, Suha, Symonds, Peter, Al Omari, Abdullah, Daniels, Ian, Shah, Sabaria, Choudhury, Ruhul Hasan, Weston, Daisy, Metheringham, Rachael, Brentville, Victoria, Durrant, Lindy
Publicado 2022

Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses

por Brentville, Victoria A, Metheringham, Rachael L, Daniels, Ian, Atabani, Suha, Symonds, Peter, Cook, Katherine W, Vankemmelbeke, Mireille, Choudhury, Ruhul, Vaghela, Poonam, Gijon, Mohamed, Meiners, Ghislaine, Krebber, Willem-Jan, Melief, Cornelis J M, Durrant, Lindy G
Publicado 2020

Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy

por Cook, Katherine W, Xue, Wei, Symonds, Peter, Daniels, Ian, Gijon, Mohamed, Boocock, David, Coveney, Clare, Miles, Amanda K, Shah, Sabaria, Atabani, Suha, Choudhury, Ruhul H, Vaghela, Poonam, Weston, Daisy, Metheringham, Rachael L, Brentville, Victoria A, Durrant, Lindy G
Publicado 2021

Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical...

por Patel, Poulam M., Ottensmeier, Christian H., Mulatero, Clive, Lorigan, Paul, Plummer, Ruth, Pandha, Hardev, Elsheikh, Somaia, Hadjimichael, Efthymios, Villasanti, Naty, Adams, Sally E., Cunnell, Michelle, Metheringham, Rachael L., Brentville, Victoria A., Machado, Lee, Daniels, Ian, Gijon, Mohamed, Hannaman, Drew, Durrant, Lindy G.
Publicado 2018