Heritable Stochastic Switching Revealed by Single-Cell Genealogy

por Kaufmann, Benjamin B, Yang, Qiong, Mettetal, Jerome T, van Oudenaarden, Alexander
Publicado 2007

Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity

por Fornari, Chiara, Pin, Carmen, Yates, James W.T., Mettetal, Jerome T., Collins, Teresa A.
Publicado 2020

Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia

por Patel, Mayankbhai, Palani, Santhosh, Chakravarty, Arijit, Yang, Johnny, Shyu, Wen Chyi, Mettetal, Jerome T.
Publicado 2014

Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules

por Shankaran, Harish, Cronin, Anna, Barnes, Jen, Sharma, Pradeep, Tolsma, John, Jasper, Paul, Mettetal, Jerome T.
Publicado 2017

Growth Rate Analysis and Efficient Experimental Design for Tumor Xenograft Studies

por Hather, Gregory, Liu, Ray, Bandi, Syamala, Mettetal, Jerome, Manfredi, Mark, Shyu, Wen-Chyi, Donelan, Jill, Chakravarty, Arijit
Publicado 2014

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

por Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Publicado 2018

Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

por Trame, Mirjam N., Riggs, Matthew, Biliouris, Konstantinos, Marathe, Dhananjay, Mettetal, Jerome, Post, Teun M., Rizk, Matthew L., Visser, Sandra A. G., Musante, Cynthia J.
Publicado 2018

Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

por Fornari, Chiara, Oplustil O'Connor, Lenka, Pin, Carmen, Smith, Aaron, Yates, James W.T., Cheung, S.Y. Amy, Jodrell, Duncan I., Mettetal, Jerome T., Collins, Teresa A.
Publicado 2019

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

por Nijsen, Marjoleen J.M.A., Wu, Fan, Bansal, Loveleena, Bradshaw‐Pierce, Erica, Chan, Jason R., Liederer, Bianca M., Mettetal, Jerome T., Schroeder, Patricia, Schuck, Edgar, Tsai, Alice, Xu, Christine, Chimalakonda, Anjaneya, Le, Kha, Penney, Mark, Topp, Brian, Yamada, Akihiro, Spilker, Mary E.
Publicado 2018

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

por McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna
Publicado 2019