Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2

por Vester, Karen, Metz, Alexander, Huber, Simon, Loll, Bernhard, Wahl, Markus C.
Publicado 2023

Towards targeting protein-protein interfaces with small molecules

por Gohlke, Holger, Metz, Alexander, Pfleger, Christopher, Krüger, Dennis M, Kazemi, Sina
Publicado 2011

Redesigning Aldolase Stereoselectivity by Homologous Grafting

por Bisterfeld, Carolin, Classen, Thomas, Küberl, Irene, Henßen, Birgit, Metz, Alexander, Gohlke, Holger, Pietruszka, Jörg
Publicado 2016

Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-...

por Ehrmann, Frederik Rainer, Stojko, Johann, Metz, Alexander, Debaene, François, Barandun, Luzi Jakob, Heine, Andreas, Diederich, François, Cianférani, Sarah, Reuter, Klaus, Klebe, Gerhard
Publicado 2017

Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking

por Metz, Alexander, Wollenhaupt, Jan, Glöckner, Steffen, Messini, Niki, Huber, Simon, Barthel, Tatjana, Merabet, Ahmed, Gerber, Hans-Dieter, Heine, Andreas, Klebe, Gerhard, Weiss, Manfred S.
Publicado 2021

Probing ligand binding of endothiapepsin by ‘temperature-resolved’ macromolecular crystallography

por Huang, Chia-Ying, Aumonier, Sylvain, Engilberge, Sylvain, Eris, Deniz, Smith, Kate Mary Louise, Leonarski, Filip, Wojdyla, Justyna Aleksandra, Beale, John H., Buntschu, Dominik, Pauluhn, Anuschka, Sharpe, May Elizabeth, Metz, Alexander, Olieric, Vincent, Wang, Meitian
Publicado 2022