Differentiation defects in primary motoneurons from a SMARD1 mouse model that are insensitive to treatment with low dose PEGylated IGF1

por Krieger, Frank, Metzger, Friedrich, Jablonka, Sibylle
Publicado 2014

Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress

por Seifi, Mohsen, Corteen, Nicole L., van der Want, Johannes J., Metzger, Friedrich, Swinny, Jerome D.
Publicado 2014

PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia

por Parker, Kim, Berretta, Antonio, Saenger, Stefanie, Sivaramakrishnan, Manaswini, Shirley, Simon A., Metzger, Friedrich, Clarkson, Andrew N.
Publicado 2017

Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

por Walz, Michael, Chau, Luong, Walz, Christina, Sawitzky, Mandy, Ohde, Daniela, Brenmoehl, Julia, Tuchscherer, Armin, Langhammer, Martina, Metzger, Friedrich, Höflich, Christine, Hoeflich, Andreas
Publicado 2020

Nerve sprouting capacity in a pharmacologically induced mouse model of spinal muscular atrophy

por Rimer, Mendell, Seaberg, Bonnie L., Yen, Pei-Fen, Lam, Steven, Hastings, Robert Louis, Lee, Young il, Thompson, Wesley J., Feng, Zhihua, Metzger, Friedrich, Paushkin, Sergey, Ko, Chien-Ping
Publicado 2019

Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

por Antony, Justin S., Birrer, Pascale, Bohnert, Claudia, Zimmerli, Sina, Hillmann, Petra, Schaffhauser, Hervé, Hoeflich, Christine, Hoeflich, Andreas, Khairallah, Ramzi, Satoh, Andreas T., Kappeler, Isabelle, Ferreira, Isabel, Zuideveld, Klaas P., Metzger, Friedrich
Publicado 2023

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD‐deficient IGFBP‐2 variant in female transgenic mice

por Hoeflich, Andreas, Reyer, Anja, Ohde, Daniela, Schindler, Nancy, Brenmoehl, Julia, Spitschak, Marion, Langhammer, Martina, Tuchscherer, Armin, Wirthgen, Elisa, Renner‐Müller, Ingrid, Wanke, Rüdiger, Metzger, Friedrich, Bielohuby, Maximilian, Wolf, Eckhard
Publicado 2015

Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes

por Hellbach, Nicole, Peterson, Suzanne, Haehnke, Daniel, Shankar, Aditi, LaBarge, Samuel, Pivaroff, Cullen, Saenger, Stefanie, Thomas, Carolin, McCarthy, Kathleen, Ebeling, Martin, Hayhurst Bennett, Monica, Schmidt, Uli, Metzger, Friedrich
Publicado 2018

Molecular, Physiological, and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus

por Huguet, Aline, Medja, Fadia, Nicole, Annie, Vignaud, Alban, Guiraud-Dogan, Céline, Ferry, Arnaud, Decostre, Valérie, Hogrel, Jean-Yves, Metzger, Friedrich, Hoeflich, Andreas, Baraibar, Martin, Gomes-Pereira, Mário, Puymirat, Jack, Bassez, Guillaume, Furling, Denis, Munnich, Arnold, Gourdon, Geneviève
Publicado 2012

Phenotype Selection Reveals Coevolution of Muscle Glycogen and Protein and PTEN as a Gate Keeper for the Accretion of Muscle Mass in Adult Female Mice

por Sawitzky, Mandy, Zeissler, Anja, Langhammer, Martina, Bielohuby, Maximilian, Stock, Peggy, Hammon, Harald M., Görs, Solvig, Metges, Cornelia C., Stoehr, Barbara J. M., Bidlingmaier, Martin, Fromm-Dornieden, Carolin, Baumgartner, Bernhard G., Christ, Bruno, Brenig, Bertram, Binder, Gerhard, Metzger, Friedrich, Renne, Ulla, Hoeflich, Andreas
Publicado 2012

Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy

por Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Mollin, Anna, Sheedy, Josephine, Yeh, Shirley, Petruska, Janet, Narasimhan, Jana, Dakka, Amal, Welch, Ellen M., Karp, Gary, Chen, Karen S., Metzger, Friedrich, Ratni, Hasane, Lotti, Francesco, Tisdale, Sarah, Naryshkin, Nikolai A., Pellizzoni, Livio, Paushkin, Sergey, Ko, Chien-Ping, Weetall, Marla
Publicado 2016

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

por Garcia-Lopez, Amparo, Tessaro, Francesca, Jonker, Hendrik R. A., Wacker, Anna, Richter, Christian, Comte, Arnaud, Berntenis, Nikolaos, Schmucki, Roland, Hatje, Klas, Petermann, Olivier, Chiriano, Gianpaolo, Perozzo, Remo, Sciarra, Daniel, Konieczny, Piotr, Faustino, Ignacio, Fournet, Guy, Orozco, Modesto, Artero, Ruben, Metzger, Friedrich, Ebeling, Martin, Goekjian, Peter, Joseph, Benoît, Schwalbe, Harald, Scapozza, Leonardo
Publicado 2018

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

por Sivaramakrishnan, Manaswini, McCarthy, Kathleen D., Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N., Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R., Allain, Frédéric H.-T., Metzger, Friedrich
Publicado 2017