Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

por Ichikawa, Tomonaga, Li, Jinqing, Meyer, Colin J., Janicki, Joseph S., Hannink, Mark, Cui, Taixing
Publicado 2009

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

por Dinkova-Kostova, Albena T., Baird, Liam, Holmström, Kira M., Meyer, Colin J., Abramov, Andrey Y.
Publicado 2015

Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2—lessons from evolution, the animal kingdom and rare progeroid syndrome...

por Stenvinkel, Peter, Meyer, Colin J, Block, Geoffrey A, Chertow, Glenn M, Shiels, Paul G
Publicado 2019

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Khazaeli, Mahyar, Yuan, Jun, Meyer, Colin J.
Publicado 2014

Orphan Drugs In Development For The Treatment Of Friedreich’s Ataxia: Focus On Omaveloxolone

por Ghanekar, Shaila D, Miller, Wai Wai, Meyer, Colin J, Fenelon, Kevin J, Lacdao, Alvin, Zesiewicz, Theresa A
Publicado 2019

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease()

por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Shelkovnikov, Stan, Farzaneh, Seyed H., Khazaeli, Mahyar, Meyer, Colin J.
Publicado 2013

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

por Tan, Yi, Ichikawa, Tomonaga, Li, Jinqing, Si, Qiusheng, Yang, Huaitao, Chen, Xiangbai, Goldblatt, Curtis S., Meyer, Colin J., Li, Xiaokun, Cai, Lu, Cui, Taixing
Publicado 2011

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

por Reisman, Scott A., Goldsberry, Angela R., Lee, Chun-Yue I., O’Grady, Megan L., Proksch, Joel W., Ward, Keith W., Meyer, Colin J.
Publicado 2015

The synthetic triterpenoid, RTA405, increases glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells

por Ding, Yanfeng, Stidham, Rhesa, Bumeister, Ron, Trevino, Isaac, Winters, Ali, Sprouse, Marc, Ding, Min, Ferguson, Deborah A., Meyer, Colin J., Wigley, W. Christian, Ma, Rong
Publicado 2012

Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

por Xing, Yifan, Niu, Ting, Wang, Wenjuan, Li, Jinqing, Li, Siying, Janicki, Joseph S., Ruiz, Stacey, Meyer, Colin J., Wang, Xing Li, Tang, Dongqi, Zhao, Yuxia, Cui, Taixing
Publicado 2012

Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function

por Nagasu, Hajime, Sogawa, Yuji, Kidokoro, Kengo, Itano, Seiji, Yamamoto, Toshiya, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Wigley, W. Christian, Proksch, Joel W., Meyer, Colin J., Kashihara, Naoki
Publicado 2019

Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

por Lewis, James H., Jadoul, Michel, Block, Geoffrey A., Chin, Melanie P., Ferguson, Deborah A., Goldsberry, Angie, Meyer, Colin J., O’Grady, Megan, Pergola, Pablo E., Reisman, Scott A., Wigley, W. Christian, Chertow, Glenn M.
Publicado 2020

Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

por Lynch, David R., Chin, Melanie P., Delatycki, Martin B., Subramony, S. H., Corti, Manuela, Hoyle, J. Chad, Boesch, Sylvia, Nachbauer, Wolfgang, Mariotti, Caterina, Mathews, Katherine D., Giunti, Paola, Wilmot, George, Zesiewicz, Theresa, Perlman, Susan, Goldsberry, Angie, O'Grady, Megan, Meyer, Colin J.
Publicado 2020

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

por Creelan, Ben C, Gabrilovich, Dmitry I, Gray, Jhanelle E, Williams, Charles C, Tanvetyanon, Tawee, Haura, Eric B, Weber, Jeffrey S, Gibney, Geoffrey T, Markowitz, Joseph, Proksch, Joel W, Reisman, Scott A, McKee, Mark D, Chin, Melanie P, Meyer, Colin J, Antonia, Scott J
Publicado 2017