Distinct biological activity of Lewy body α-Synuclein strain in mice

por Uemura, Norihito, Marotta, Nicholas, Ara, Jahan, Meymand, Emily, Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin, Trojanowski, John, Lee, Virginia
Publicado 2023

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

por Marotta, Nicholas P., Ara, Jahan, Uemura, Norihito, Lougee, Marshall G., Meymand, Emily S., Zhang, Bin, Petersson, E. James, Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2021

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

por Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2023

α-Synuclein modulates tau spreading in mouse brains

por Bassil, Fares, Meymand, Emily S., Brown, Hannah J., Xu, Hong, Cox, Timothy O., Pattabhiraman, Shankar, Maghames, Chantal M., Wu, Qihui, Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2020

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

por Gibbons, Garrett S., Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M., Leight, Susan N., Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S., O’Reilly, Mia, Zhang, Bin, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M. Y.
Publicado 2020

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

por Delizannis, Argyro Thalia, Nonneman, Annelies, Tsering, Wangchen, De Bondt, An, Van den Wyngaert, Ilse, Zhang, Bin, Meymand, Emily, Olufemi, Modupe F., Koivula, Pyry, Maimaiti, Shaniya, Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R.
Publicado 2021