BCR: a new target in resistance mediated by BCR/ABL-315I?

por Haberbosch, Isabella, Rafiei, Anahita, Oancea, Claudia, Ottmann, Gerhart Oliver, Ruthardt, Martin, Mian, Afsar Ali
Publicado 2016

AXL receptor tyrosine kinase: a possible therapeutic target in acute promyelocytic leukemia

por Fatima, Mariam, Kakar, Salik Javed, Adnan, Fazal, Khan, Khalid, Mian, Afsar Ali, Khan, Dilawar
Publicado 2021

Oncogene-independent resistance in Philadelphia chromosome - positive (Ph(+)) acute lymphoblastic leukemia (ALL) is mediated by activation of AKT/mTOR pathway

por Mian, Afsar Ali, Zafar, Usva, Ahmed, Syed Muhammad Areeb, Ottmann, Oliver Gerhard, Lalani, El-Nasir M A
Publicado 2021

Lyophilization Based Isolation of Exosomes

por Qazi, Rida e Maria, Sajid, Zahra, Zhao, Chunqiu, Hussain, Irfan, Iftikhar, Fizza, Jameel, Muhammad, Rehman, Fawad Ur, Mian, Afsar Ali
Publicado 2023

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

por Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin
Publicado 2012

The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia

por Rafiei, Anahita, Mian, Afsar Ali, Döring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B., Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin
Publicado 2015

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML

por Oancea, Claudia, Rüster, Brigitte, Brill, Boris, Roos, Jessica, Heinssmann, Maria, Bug, Gesine, Mian, Afsar Ali, Guillen, Nathalie Andrea, Kornblau, Steven M., Henschler, Reinhard, Ruthardt, Martin
Publicado 2014

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and...

por Mian, Afsar Ali, Haberbosch, Isabella, Khamaisie, Hazem, Agbarya, Abed, Pietsch, Larissa, Eshel, Elizabeh, Najib, Dally, Chiriches, Claudia, Ottmann, Oliver Gerhard, Hantschel, Oliver, Biondi, Ricardo M., Ruthardt, Martin, Mahajna, Jamal
Publicado 2021