The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling

por Allegaert, Karel, Abbasi, Mohammad Yaseen, Michelet, Robin, Olafuyi, Olusola
Publicado 2022

Microdialysis of Drug and Drug Metabolite: a Comprehensive In Vitro Analysis for Voriconazole and Voriconazole N-oxide

por Schulz, Josefine, Michelet, Robin, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2022

Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans

por Schulz, Josefine, Michelet, Robin, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2022

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

por Mueller-Schoell, Anna, Michelet, Robin, Weinelt, Ferdinand, Kloft, Charlotte, Mikus, Gerd
Publicado 2021

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

por Kluwe, Franziska, Michelet, Robin, Huisinga, Wilhelm, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2023

Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism

por Schulz, Josefine, Thomas, Antonia, Saleh, Ayatallah, Mikus, Gerd, Kloft, Charlotte, Michelet, Robin
Publicado 2022

Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli

por Seeger, Johanna, Guenther, Sebastian, Schaufler, Katharina, Heiden, Stefan E., Michelet, Robin, Kloft, Charlotte
Publicado 2021

A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice

por Franck, Sebastian, Michelet, Robin, Casilag, Fiordiligie, Sirard, Jean-Claude, Wicha, Sebastian G., Kloft, Charlotte
Publicado 2021

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by Levofloxacin

por Busse, David, Schaeftlein, André, Solms, Alexander, Ilia, Luis, Michelet, Robin, Zeitlinger, Markus, Huisinga, Wilhelm, Kloft, Charlotte
Publicado 2021

Cost-effectiveness of oral anticancer drugs and associated individualised dosing approaches in patients with cancer: protocol for a systematic review

por van Dyk, Madelé, Bulamu, Norma, Boylan, Chelsea, Mc Laughlin, Anna M, Kichenadasse, Ganessan, May, Nikki, Michelet, Robin, Kloft, Charlotte, Kaambwa, Billingsley
Publicado 2021

Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

por Stachanow, Viktoria, Neumann, Uta, Blankenstein, Oliver, Bindellini, Davide, Melin, Johanna, Ross, Richard, Whitaker, Martin J., Huisinga, Wilhelm, Michelet, Robin, Kloft, Charlotte
Publicado 2022

Development of a Model-Informed Dosing Tool to Optimise Initial Antibiotic Dosing—A Translational Example for Intensive Care Units

por Weinelt, Ferdinand Anton, Stegemann, Miriam Songa, Theloe, Anja, Pfäfflin, Frieder, Achterberg, Stephan, Schmitt, Lisa, Huisinga, Wilhelm, Michelet, Robin, Hennig, Stefanie, Kloft, Charlotte
Publicado 2021

Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

por Busse, David, Simon, Philipp, Schmitt, Lisa, Petroff, David, Dorn, Christoph, Dietrich, Arne, Zeitlinger, Markus, Huisinga, Wilhelm, Michelet, Robin, Wrigge, Hermann, Kloft, Charlotte
Publicado 2021

Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach

por Michelet, Robin, Bindellini, Davide, Melin, Johanna, Neumann, Uta, Blankenstein, Oliver, Huisinga, Wilhelm, Johnson, Trevor N., Whitaker, Martin J., Ross, Richard, Kloft, Charlotte
Publicado 2023

C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework

por Nassar, Yomna M., Ojara, Francis Williams, Pérez-Pitarch, Alejandro, Geiger, Kimberly, Huisinga, Wilhelm, Hartung, Niklas, Michelet, Robin, Holdenrieder, Stefan, Joerger, Markus, Kloft, Charlotte
Publicado 2023

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

por Nassar, Yomna M., Hohmann, Nicolas, Michelet, Robin, Gottwalt, Katharina, Meid, Andreas D., Burhenne, Jürgen, Huisinga, Wilhelm, Haefeli, Walter E., Mikus, Gerd, Kloft, Charlotte
Publicado 2022

Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies

por Mueller-Schoell, Anna, Klopp-Schulze, Lena, Michelet, Robin, van Dyk, Madelé, Mürdter, Thomas E., Schwab, Matthias, Joerger, Markus, Huisinga, Wilhelm, Mikus, Gerd, Kloft, Charlotte
Publicado 2021

Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups

por Mueller-Schoell, Anna, Michelet, Robin, Klopp-Schulze, Lena, van Dyk, Madelé, Mürdter, Thomas E., Schwab, Matthias, Joerger, Markus, Huisinga, Wilhelm, Mikus, Gerd, Kloft, Charlotte
Publicado 2021

Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review

por Démaris, Alix, Widigson, Ella S. K., Ilvemark, Johan F. K. F., Steenholdt, Casper, Seidelin, Jakob B., Huisinga, Wilhelm, Michelet, Robin, Aulin, Linda B. S., Kloft, Charlotte
Publicado 2022

Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model

por Mueller-Schoell, Anna, Puebla-Osorio, Nahum, Michelet, Robin, Green, Michael R., Künkele, Annette, Huisinga, Wilhelm, Strati, Paolo, Chasen, Beth, Neelapu, Sattva S., Yee, Cassian, Kloft, Charlotte
Publicado 2021