Autophagy in Trypanosomatids

por Brennand, Ana, Rico, Eva, Michels, Paul A. M.
Publicado 2012

Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

por Gupta, Shreedhara, Igoillo-Esteve, Mariana, Michels, Paul A. M., Cordeiro, Artur T.
Publicado 2011

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

por Zíková, Alena, Verner, Zdeněk, Nenarokova, Anna, Michels, Paul A. M., Lukeš, Julius
Publicado 2017

Antimicrobial Peptides (AMPs): Potential Therapeutic Strategy against Trypanosomiases?

por Rojas-Pirela, Maura, Kemmerling, Ulrike, Quiñones, Wilfredo, Michels, Paul A. M., Rojas, Verónica
Publicado 2023

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

por Fernandes, Peter M., Kinkead, James, McNae, Iain, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado 2020

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

por Nare, Zandile, Moses, Tessa, Burgess, Karl, Schnaufer, Achim, Walkinshaw, Malcolm D., Michels, Paul A. M.
Publicado 2023

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei

por Brennand, Ana, Rico, Eva, Rigden, Daniel J., Van Der Smissen, Patrick, Courtoy, Pierre J., Michels, Paul A. M.
Publicado 2015

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

por Marchese, Letícia, Nascimento, Janaina de Freitas, Damasceno, Flávia Silva, Bringaud, Frédéric, Michels, Paul A. M., Silber, Ariel Mariano
Publicado 2018

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

por Fernandes, Peter M., Kinkead, James, McNae, Iain W., Bringaud, Frédéric, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado 2019

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

por Quiñones, Wilfredo, Acosta, Héctor, Gonçalves, Camila Silva, Motta, Maria Cristina M., Gualdrón-López, Melisa, Michels, Paul A. M.
Publicado 2020

Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target

por Avilán, Luisana, Gualdrón-López, Melisa, Quiñones, Wilfredo, González-González, Limari, Hannaert, Véronique, Michels, Paul A. M., Concepción, Juan-Luis
Publicado 2011

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

por Gualdron-López, Melisa, Vapola, Miia H., Miinalainen, Ilkka J., Hiltunen, J. Kalervo, Michels, Paul A. M., Antonenkov, Vasily D.
Publicado 2012

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

por Morgan, Hugh P., Zhong, Wenhe, McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado 2014

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

por Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado 2017

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogen...

por Fernandes, Peter M., Kinkead, James, McNae, Iain W., Vásquez‐Valdivieso, Monserrat, Wear, Martin A., Michels, Paul A. M., Walkinshaw, Malcolm D.
Publicado 2020

Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists

por Andrade-Alviárez, Diego, Bonive-Boscan, Alejandro D., Cáceres, Ana J., Quiñones, Wilfredo, Gualdrón-López, Melisa, Ginger, Michael L., Michels, Paul A. M.
Publicado 2022

Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes

por Acosta, Héctor, Burchmore, Richard, Naula, Christina, Gualdrón-López, Melisa, Quintero-Troconis, Ender, Cáceres, Ana J., Michels, Paul A.M., Concepción, Juan Luis, Quiñones, Wilfredo
Publicado 2019

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

por Alloatti, Andrés, Gupta, Shreedhara, Gualdrón-López, Melisa, Igoillo-Esteve, Mariana, Nguewa, Paul A., Deumer, Gladys, Wallemacq, Pierre, Altabe, Silvia G., Michels, Paul A. M., Uttaro, Antonio D.
Publicado 2010

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

por Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Publicado 2018

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

por González-Chávez, Zabdi, Vázquez, Citlali, Mejia-Tlachi, Marlen, Márquez-Dueñas, Claudia, Manning-Cela, Rebeca, Encalada, Rusely, Rodríguez-Enríquez, Sara, Michels, Paul A.M., Moreno-Sánchez, Rafael, Saavedra, Emma
Publicado 2019