Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling

por Zhang, Qiang, Li, Jin, Middleton, Alistair, Bhattacharya, Sudin, Conolly, Rory B.
Publicado 2018

An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors

por Stichel, Damian, Middleton, Alistair M., Müller, Benedikt F., Depner, Sofia, Klingmüller, Ursula, Breuhahn, Kai, Matthäus, Franziska
Publicado 2017

Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment

por Hatherell, Sarah, Baltazar, Maria T, Reynolds, Joe, Carmichael, Paul L, Dent, Matthew, Li, Hequn, Ryder, Stephanie, White, Andrew, Walker, Paul, Middleton, Alistair M
Publicado 2020

Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1

por Zhang, Li, Guo, Jiabin, Zhang, Qiang, Zhou, Wei, Li, Jin, Yin, Jian, Cui, Lan, Zhang, Tingfen, Zhao, Jun, Carmichael, Paul L., Middleton, Alistair, Peng, Shuangqing
Publicado 2018

Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data

por Basili, Danilo, Reynolds, Joe, Houghton, Jade, Malcomber, Sophie, Chambers, Bryant, Liddell, Mark, Muller, Iris, White, Andrew, Shah, Imran, Everett, Logan J., Middleton, Alistair, Bender, Andreas
Publicado 2022

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow

por Middleton, Alistair M, Reynolds, Joe, Cable, Sophie, Baltazar, Maria Teresa, Li, Hequn, Bevan, Samantha, Carmichael, Paul L, Dent, Matthew Philip, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Liddell, Mark, Malcomber, Sophie, Nicol, Beate, Park, Benjamin, Patel, Hiral, Scott, Sharon, Sparham, Chris, Walker, Paul, White, Andrew
Publicado 2022

A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products

por Baltazar, Maria T, Cable, Sophie, Carmichael, Paul L, Cubberley, Richard, Cull, Tom, Delagrange, Mona, Dent, Matthew P, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Li, Hequn, Lee, Mi-Young, Malcomber, Sophie, Middleton, Alistair M, Moxon, Thomas E, Nathanail, Alexis V, Nicol, Beate, Pendlington, Ruth, Reynolds, Georgia, Reynolds, Joe, White, Andrew, Westmoreland, Carl
Publicado 2020

Sequential induction of auxin efflux and influx carriers regulates lateral root emergence

por Péret, Benjamin, Middleton, Alistair M, French, Andrew P, Larrieu, Antoine, Bishopp, Anthony, Njo, Maria, Wells, Darren M, Porco, Silvana, Mellor, Nathan, Band, Leah R, Casimiro, Ilda, Kleine-Vehn, Jürgen, Vanneste, Steffen, Sairanen, Ilkka, Mallet, Romain, Sandberg, Göran, Ljung, Karin, Beeckman, Tom, Benkova, Eva, Friml, Jiří, Kramer, Eric, King, John R, De Smet, Ive, Pridmore, Tony, Owen, Markus, Bennett, Malcolm J
Publicado 2013