Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System

por Miedel, Mark T., Gavlock, Dillon C., Jia, Shanhang, Gough, Albert, Taylor, D. Lansing, Stern, Andrew M.
Publicado 2019

Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis

por Miedel, Mark T., Rbaibi, Youssef, Guerriero, Christopher J., Colletti, Grace, Weixel, Kelly M., Weisz, Ora A., Kiselyov, Kirill
Publicado 2008

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

por Miedel, Mark T., Graf, Nathan J., Stephen, Kate E., Long, Olivia S., Pak, Stephen C., Perlmutter, David H., Silverman, Gary A., Luke, Cliff J.
Publicado 2012

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

por Cummings, Erin E., O’Reilly, Linda P., King, Dale E., Silverman, Richard M., Miedel, Mark T., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Publicado 2015

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanist...

por Beaudoin, James J., Clemens, Lara, Miedel, Mark T., Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E., Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K. M., Siler, Scott Q., Taylor, D. Lansing, Howell, Brett A., Vernetti, Lawrence A., Yang, Kyunghee
Publicado 2023

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants

por Faccioli, Lanuza A. P., Cetin, Zeliha, Kocas-Kilicarslan, Zehra N., Ortiz, Kimberly, Sun, Yiyue, Hu, Zhiping, Kurihara, Takeshi, Tafaleng, Edgar N., Florentino, Rodrigo M., Wang, Zi, Xia, Mengying, Miedel, Mark T., Taylor, D. Lansing, Behari, Jaideep, Ostrowska, Alina, Constantine, Robert, Li, Albert, Soto-Gutierrez, Alejandro
Publicado 2023

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

por Lefever, Daniel E., Miedel, Mark T., Pei, Fen, DiStefano, Johanna K., Debiasio, Richard, Shun, Tong Ying, Saydmohammed, Manush, Chikina, Maria, Vernetti, Lawrence A., Soto-Gutierrez, Alejandro, Monga, Satdarshan P., Bataller, Ramon, Behari, Jaideep, Yechoor, Vijay K., Bahar, Ivet, Gough, Albert, Stern, Andrew M., Taylor, D. Lansing
Publicado 2022

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

por Luke, Cliff J., Markovina, Stephanie, Good, Misty, Wight, Ira E., Thomas, Brian J., Linneman, John M., Lanik, Wyatt E., Koroleva, Olga, Coffman, Maggie R., Miedel, Mark T., Gong, Qingqing, Andress, Arlise, Campos Guerrero, Marlene, Wang, Songyan, Chen, LiYun, Beatty, Wandy L., Hausmann, Kelsey N., White, Frances V., Fitzpatrick, James A. J., Orvedahl, Anthony, Pak, Stephen C., Silverman, Gary A.
Publicado 2022

Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development

por Berzofsky, Jay A., Koch, Lauren Gerard, Britton, Steven L., Chen, Shaochen, Zhu, Wei, Ma, Xuanyi, Comuzzie, Anthony G., Devy-Dimanche, Laetitia, Feaver, Ryan, Grimm, Jan, Hock, Christoph, Nitsch, Roger M., Hoying, James B., Lusis, Aldons J., Marincola, Francesco, Samayoa, Josue, Turan, Tolga, Pearce, David A., Nurmi, Antti, Huhtala, Tuulia, Shatillo, Artem, Puoliväli, Jukka, Heikkinen, Taneli, Bragge, Timo, Lehtimäki, Kimmo, Sanyal, Arun J., Strange, Kevin, Taylor, D. Lansing, Miedel, Mark, Jia, Shanhang, Soto-Guterriez, Alex, Stern, Andrew, Gough, Albert
Publicado 2017