Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

por Wiebe, Sabrina T., Meid, Andreas D., Mikus, Gerd
Publicado 2020

Drug–Drug Interactions with Direct Oral Anticoagulants

por Foerster, Kathrin I., Hermann, Simon, Mikus, Gerd, Haefeli, Walter E.
Publicado 2020

Correction to: Drug–Drug Interactions with Direct Oral Anticoagulants

por Foerster, Kathrin I., Hermann, Simon, Mikus, Gerd, Haefeli, Walter E.
Publicado 2020

Microdialysis of Drug and Drug Metabolite: a Comprehensive In Vitro Analysis for Voriconazole and Voriconazole N-oxide

por Schulz, Josefine, Michelet, Robin, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2022

Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans

por Schulz, Josefine, Michelet, Robin, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2022

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

por Mueller-Schoell, Anna, Michelet, Robin, Weinelt, Ferdinand, Kloft, Charlotte, Mikus, Gerd
Publicado 2021

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

por Kluwe, Franziska, Michelet, Robin, Huisinga, Wilhelm, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Publicado 2023

Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism

por Schulz, Josefine, Thomas, Antonia, Saleh, Ayatallah, Mikus, Gerd, Kloft, Charlotte, Michelet, Robin
Publicado 2022

Pharmacokinetics of a microdosed cocktail of three direct oral anticoagulants in children with congenital heart defects: study protocol for a single-centre clinical trial (DOAC-Chi...

por Hermann, Simon A, Mikus, Gerd, Chobanyan-Jürgens, Kristine, Gorenflo, Matthias, Ziesenitz, Victoria C.
Publicado 2023

Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers

por Ammon, Susanne, Marx, Claudia, Behrens, Christoph, Hofmann, Ute, Mürdter, Thomas, Griese, Ernst-Ulrich, Mikus, Gerd
Publicado 2002

Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug–drug interactions with different perpetrator drugs

por Mikus, Gerd, Foerster, Kathrin I., Schaumaeker, Marlene, Lehmann, Marie‐Louise, Burhenne, Jürgen, Haefeli, Walter E.
Publicado 2020

Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges

por van Leuven, Jason, Evans, Simon, Kichenadasse, Ganessan, Steeghs, Neeltje, Bonevski, Billie, Mikus, Gerd, van Dyk, Madelé
Publicado 2023

Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients

por Geist, Marcus J. P., Ziesenitz, Victoria C., Bardenheuer, Hubert J., Burhenne, Juergen, Skopp, Gisela, Mikus, Gerd
Publicado 2019

Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial

por Vay, Manuela, Meyer, Marleen Julia, Blank, Antje, Skopp, Gisela, Rose, Peter, Tzvetkov, Mladen Vassilev, Mikus, Gerd
Publicado 2020

Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans

por Elbe, Annika, Foerster, Kathrin Isabelle, Blank, Antje, Rose, Peter, Burhenne, Jürgen, Haefeli, Walter Emil, Mikus, Gerd
Publicado 2022

Pharmacoenhancement of Low Crizotinib Plasma Concentrations in Patients with Anaplastic Lymphoma Kinase‐Positive Non‐Small Cell Lung Cancer using the CYP3A Inhibitor Cobicistat

por Hohmann, Nicolas, Bozorgmehr, Farastuk, Christopoulos, Petros, Mikus, Gerd, Blank, Antje, Burhenne, Jürgen, Thomas, Michael, Haefeli, Walter E.
Publicado 2020

Perpetrator Characteristics of Azole Antifungal Drugs on Three Oral Factor Xa Inhibitors Administered as a Microdosed Cocktail

por Rohr, Brit Silja, Foerster, Kathrin Isabelle, Blank, Antje, Burhenne, Jürgen, Mahmoudi, Mazyar, Haefeli, Walter Emil, Mikus, Gerd
Publicado 2021

CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults

por Muhareb, Amin, Blank, Antje, Meid, Andreas D., Foerster, Kathrin I., Stoll, Felicitas, Burhenne, Jürgen, Haefeli, Walter E., Mikus, Gerd
Publicado 2023

How to Interpret an Investigator’s Brochure for Meaningful Risk Assessment: Results of an AGAH Discussion Forum

por Rengelshausen, Jens, Breithaupt-Groegler, Kerstin, Donath, Frank, Erb-Zohar, Katharina, Hardman, Tim, Mikus, Gerd, Plassmann, Stephanie, Wensing, Georg, Sourgens, Hildegard
Publicado 2021

Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

por Zhu, Vanessa, Burhenne, Jürgen, Weiss, Johanna, Haag, Mathias, Hofmann, Ute, Schwab, Matthias, Urban, Stephan, Mikus, Gerd, Czock, David, Haefeli, Walter E., Blank, Antje
Publicado 2023