Method development and validation for analysis of phenylalanine, 4‐hydroxyphenyllactic acid and 4‐hydroxyphenylpyruvic acid in serum and urine

por Hughes, Andrew T., Milan, Anna M., Shweihdi, Ella, Gallagher, James, Ranganath, Lakshminarayan
Publicado 2022

Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria

por Davison, Andrew S., Norman, Brendan P., Sutherland, Hazel, Milan, Anna M., Gallagher, James A., Jarvis, Jonathan C., Ranganath, Lakshminarayan R.
Publicado 2022

Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS

por Davison, Andrew S., Norman, Brendan P., Ross, Gordon A., Hughes, Andrew T., Khedr, Milad, Milan, Anna M., Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2019

The nutritional status of people with alkaptonuria: An exploratory analysis suggests a protein/energy dilemma

por Judd, Shirley, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Hughes, Andrew T., Needham, Alexander, Psarelli, Eftychia E., Shenkin, Alan, Ranganath, Lakshiminaryan R.
Publicado 2020

Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Davison, Andrew S., Wilson, Peter J., Dillon, Jane P., West, Elizabeth, Gallagher, James A.
Publicado 2020

Increased prevalence of Parkinson's disease in alkaptonuria

por Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.
Publicado 2023

Nitisinone Treatment Affects Biomarkers of Bone and Cartilage Remodelling in Alkaptonuria Patients

por Genovese, Federica, Frederiksen, Peder, Bay-Jensen, Anne-Christine, Karsdal, Morten A., Milan, Anna M., Olsson, Birgitta, Rudebeck, Mattias, Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2023

Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard
Publicado 2021

Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen...

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A.
Publicado 2022

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

por Ranganath, Lakshminarayan R., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A., Milan, Anna M.
Publicado 2022

Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria

por Hughes, Juliette H., Wilson, Peter J. M., Sutherland, Hazel, Judd, Shirley, Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Bou‐Gharios, George, Ranganath, Lakshminarayan R., Gallagher, James A.
Publicado 2020

Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the ge...

por Hughes, Juliette H, Liu, Ke, Plagge, Antonius, Wilson, Peter J M, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao, Ranganath, Lakshminarayan R, Gallagher, James A, Bou-Gharios, George
Publicado 2019

Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

por Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM., Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.
Publicado 2021

Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

por Norman, Brendan P., Davison, Andrew S., Hickton, Bryony, Ross, Gordon A., Milan, Anna M., Hughes, Andrew T., Wilson, Peter J. M., Sutherland, Hazel, Hughes, Juliette H., Roberts, Norman B., Bou-Gharios, George, Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2022