A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independe...

por Konen, Lyndsey M., Wright, Amanda L., Royle, Gordon A., Morris, Gary P., Lau, Benjamin K., Seow, Patrick W., Zinn, Raphael, Milham, Luke T., Vaughan, Christopher W., Vissel, Bryce
Publicado 2020

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

por Wright, Amanda L., Konen, Lyndsey M., Mockett, Bruce G., Morris, Gary P., Singh, Anurag, Burbano, Lisseth Estefania, Milham, Luke, Hoang, Monica, Zinn, Raphael, Chesworth, Rose, Tan, Richard P., Royle, Gordon A., Clark, Ian, Petrou, Steven, Abraham, Wickliffe C., Vissel, Bryce
Publicado 2023