COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

por Dickens, Jennifer A, Miller, Bruce E, Edwards, Lisa D, Silverman, Edwin K, Lomas, David A, Tal-Singer, Ruth
Publicado 2011

Multiple biomarkers predict disease severity, progression and mortality in COPD

por Zemans, Rachel L., Jacobson, Sean, Keene, Jason, Kechris, Katerina, Miller, Bruce E., Tal-Singer, Ruth, Bowler, Russell P.
Publicado 2017

Validation of the Summit Lab Score in Predicting Exacerbations of Chronic Obstructive Pulmonary Disease Among Individuals with High Arterial Stiffness

por Horne, Benjamin D, Ali, Rehan, Midwinter, Dawn, Scott-Wilson, Catherine, Crim, Courtney, Miller, Bruce E, Rubin, David B
Publicado 2021

CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial

por Lazaar, Aili L., Miller, Bruce E., Donald, Alison C., Keeley, Thomas, Ambery, Claire, Russell, John, Watz, Henrik, Tal-Singer, Ruth
Publicado 2020

The COPD Foundation's COPD360Net Initiative Approach to Patient-Centric Drug Development: A Case Study in Using Patient Surveys to Inform New Treatments for Viral Respiratory Infec...

por Tal-Singer, Ruth, Miller, Bruce E, Rommes, Jean M, Luttmann, Mark A, Demaison, Christophe, Bradley Drummond, M, Pasquale, Cara B
Publicado 2023

Bacteria and sputum inflammatory cell counts; a COPD cohort analysis

por Beech, Augusta S., Lea, Simon, Kolsum, Umme, Wang, Zhang, Miller, Bruce E., Donaldson, Gavin C., Wedzicha, Jadwiga A., Brightling, Christopher E., Singh, Dave
Publicado 2020

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects

por Miller, Bruce E., Mistry, Sunil, Smart, Kevin, Connolly, Paul, Carpenter, Donald C., Cooray, Hiran, Bloomer, Jackie C., Tal-Singer, Ruth, Lazaar, Aili L.
Publicado 2015

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

por Keir, Holly R., Richardson, Hollian, Fillmore, Christina, Shoemark, Amelia, Lazaar, Aili L., Miller, Bruce E., Tal-Singer, Ruth, Chalmers, James D., Mohan, Divya
Publicado 2020

The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers

por Miller, Bruce E., Smart, Kevin, Mistry, Sunil, Ambery, Claire L., Bloomer, Jackie C., Connolly, Paul, Sanderson, Dominic, Shreeves, Trevor, Smith, Rachel, Lazaar, Aili L.
Publicado 2014

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

por Sand, Jannie M. B., Leeming, Diana J., Byrjalsen, Inger, Bihlet, Asger R., Lange, Peter, Tal-Singer, Ruth, Miller, Bruce E., Karsdal, Morten A., Vestbo, Jørgen
Publicado 2016

Biomarkers of collagen turnover are related to annual change in FEV(1) in patients with chronic obstructive pulmonary disease within the ECLIPSE study

por Leeming, Diana J., Byrjalsen, Inger, Sand, Jannie M. B., Bihlet, Asger R., Lange, Peter, Thal-Singer, Ruth, Miller, Bruce E., Karsdal, Morten A., Vestbo, Jørgen
Publicado 2017

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

por Lonergan, Mike, Dicker, Alison J., Crichton, Megan L., Keir, Holly R., Van Dyke, Melissa K., Mullerova, Hana, Miller, Bruce E., Tal-Singer, Ruth, Chalmers, James D.
Publicado 2020

Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort

por Rønnow, Sarah Rank, Sand, Jannie Marie Bülow, Langholm, Lasse Løcke, Manon-Jensen, Tina, Karsdal, Morten Asser, Tal-Singer, Ruth, Miller, Bruce E., Vestbo, Jørgen, Leeming, Diana Julie
Publicado 2019

Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk

por Langholm, Lasse L, Rønnow, Sarah Rank, Sand, Jannie M B, Leeming, Diana Julie, Tal-Singer, Ruth, Miller, Bruce E, Vestbo, Jørgen, Karsdal, Morten A, Manon-Jensen, Tina
Publicado 2020

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort

por Rønnow, Sarah R., Langholm, Lasse L., Karsdal, Morten A., Manon-Jensen, Tina, Tal-Singer, Ruth, Miller, Bruce E., Vestbo, Jørgen, Leeming, Diana J., Sand, Jannie M. B.
Publicado 2020

Combining biomarkers of clot resolution and alveolar basement membrane destruction predicts mortality in the ECLIPSE COPD cohort

por Sand, Jannie M.B., Rønnow, Sarah R., Langholm, Lasse L., Karsdal, Morten A., Manon-Jensen, Tina, Tal-Singer, Ruth, Miller, Bruce E., Vestbo, Jørgen, Leeming, Diana J.
Publicado 2020

Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA

por Pavey, Holly, Polkey, Michael I, Bolton, Charlotte E, Cheriyan, Joseph, McEniery, Carmel M, Wilkinson, Ian, Mohan, Divya, Casaburi, Richard, Miller, Bruce E, Tal-Singer, Ruth, Fisk, Marie
Publicado 2023

Exhaled volatile organic compounds and lung microbiome in COPD: a pilot randomised controlled trial

por Mohan, Divya, Keir, Holly R., Richardson, Hollian, Mayhew, David, Boyer, Joseph, van der Schee, Marc P., Allsworth, Max D., Miller, Bruce E., Tal-Singer, Ruth, Chalmers, James D.
Publicado 2021

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis

por Faner, Rosa, Morrow, Jarrett D., Casas-Recasens, Sandra, Cloonan, Suzanne M., Noell, Guillaume, López-Giraldo, Alejandra, Tal-Singer, Ruth, Miller, Bruce E., Silverman, Edwin K., Agustí, Alvar, Hersh, Craig P.
Publicado 2019

Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort

por Rønnow, Sarah Rank, Langholm, Lasse Løcke, Sand, Jannie Marie Bülow, Thorlacius-Ussing, Jeppe, Leeming, Diana Julie, Manon-Jensen, Tina, Tal-Singer, Ruth, Miller, Bruce E., Karsdal, Morten Asser, Vestbo, Jørgen
Publicado 2019