Sensitivity of cholecystokinin receptors to membrane cholesterol content

por Desai, Aditya J., Miller, Laurence J.
Publicado 2012

CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours

por Körner, Meike, Waser, Beatrice, Reubi, Jean Claude, Miller, Laurence J
Publicado 2010

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

por Miller, Laurence J., Harikumar, Kaleeckal G., Wootten, Denise, Sexton, Patrick M.
Publicado 2021

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus

por Ng, Hans K. H., Harikumar, Kaleeckal G., Miller, Laurence J., Chow, Billy K. C.
Publicado 2016

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

por Ward, Richard J., Pediani, John D., Harikumar, Kaleeckal G., Miller, Laurence J., Milligan, Graeme
Publicado 2017

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

por Dengler, Daniela G., Sun, Qing, Harikumar, Kaleeckal G., Miller, Laurence J., Sergienko, Eduard A.
Publicado 2022

Mechanism of Action and Structure–Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

por Dengler, Daniela G., Harikumar, Kaleeckal G., Yen, Alice, Sergienko, Eduard A., Miller, Laurence J.
Publicado 2023

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors

por Lu, Jessica, Piper, Sarah J., Zhao, Peishen, Miller, Laurence J., Wootten, Denise, Sexton, Patrick M.
Publicado 2022

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

por Yan, Yan, Xu, Ting-Hai, Harikumar, Kaleeckal G., Miller, Laurence J., Melcher, Karsten, Xu, H. Eric
Publicado 2017

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in...

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G.B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

Modulation of β-Catenin Signaling by Glucagon Receptor Activation

por Ke, Jiyuan, Zhang, Chenghai, Harikumar, Kaleeckal G., Zylstra-Diegel, Cassandra R., Wang, Liren, Mowry, Laura E., Miller, Laurence J., Williams, Bart O., Xu, H. Eric
Publicado 2012

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

por DeBruine, Zachary J., Ke, Jiyuan, Harikumar, Kaleeckal G., Gu, Xin, Borowsky, Peter, Williams, Bart O., Xu, Wenqing, Miller, Laurence J., Xu, H. Eric, Melcher, Karsten
Publicado 2017

Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of t...

por Lomberk, Gwen, Grzenda, Adrienne, Mathison, Angela, Escande, Carlos, Zhang, Jin-San, Calvo, Ezequiel, Miller, Laurence J., Iovanna, Juan, Chini, Eduardo N., Fernandez-Zapico, Martin E., Urrutia, Raul
Publicado 2013

Prospective study of the feasibility of point-of-care testing strategy for carbapenem-resistant organism detection

por Pannala, Rahul, Baldwin, Bruce, Aluru, Vijay, Grys, Thomas E., Holmes, Jordan, Miller, Laurence J., Harrison, M. Edwyn, Nguyen, Cuong C., Tenover, Fred C., Persing, David, Faigel, Douglas O.
Publicado 2018

Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

por Ke, Jiyuan, Harikumar, Kaleeckal G., Erice, Clara, Chen, Chen, Gu, Xin, Wang, Liren, Parker, Naomi, Cheng, Zhihong, Xu, Wenqing, Williams, Bart O., Melcher, Karsten, Miller, Laurence J., Xu, H. Eric
Publicado 2013

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

por Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M., Miller, Laurence J.
Publicado 2021

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

por Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Publicado 2021

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

por de Graaf, Chris, Donnelly, Dan, Wootten, Denise, Lau, Jesper, Sexton, Patrick M., Miller, Laurence J., Ahn, Jung-Mo, Liao, Jiayu, Fletcher, Madeleine M., Yang, Dehua, Brown, Alastair J. H., Zhou, Caihong, Deng, Jiejie, Wang, Ming-Wei
Publicado 2016

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

por Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A, Wootten, Denise, Sexton, Patrick M.
Publicado 2018

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016