The Pharmacology of T Cell Therapies

por Milone, Michael C., Bhoj, Vijay G.
Publicado 2018

Clinical use of lentiviral vectors

por Milone, Michael C., O’Doherty, Una
Publicado 2018

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

por Babich, Alexander, Li, Shuixing, O'Connor, Roddy S., Milone, Michael C., Freedman, Bruce D., Burkhardt, Janis K.
Publicado 2012

Engineering enhanced CAR T-cells for improved cancer therapy

por Milone, Michael C., Xu, Jie, Chen, Sai-Juan, Collins, McKensie A., Zhou, Jiafeng, Powell, Daniel J., Melenhorst, J. Joseph
Publicado 2021

Generation of non-human primate CAR Tregs using artificial antigen-presenting cells, simian tropic lentiviral vectors, and antigen-specific restimulation

por Ellis, Gavin I., Deng, Mosha Z., Winn, Delaine W., Coker, Kimberly E., Shukla, Divanshu, Bhoj, Vijay, Milone, Michael C., Duran-Struuck, Raimon, Riley, James L.
Publicado 2022

Evaluation of a Nanoparticle-Based Busulfan Immunoassay for Rapid Analysis on Routine Clinical Analyzers

por Hilaire, Mary Rose, Gill, Regina V., Courtney, Jodi B., Baburina, Irina, Gardiner, JoAnn, Milone, Michael C., Shaw, Leslie M., Meng, Qing H., Salamone, Salvatore J.
Publicado 2021

High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

por Thokala, Radhika, Binder, Zev A., Yin, Yibo, Zhang, Logan, Zhang, Jiasi Vicky, Zhang, Daniel Y., Milone, Michael C., Ming, Guo-li, Song, Hongjun, O’Rourke, Donald M.
Publicado 2021

Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque

por Ellis, Gavin I., Coker, Kimberly E., Winn, Delaine W., Deng, Mosha Z., Shukla, Divanshu, Bhoj, Vijay, Milone, Michael C., Wang, Wei, Liu, Chengyang, Naji, Ali, Duran-Struuck, Raimon, Riley, James L.
Publicado 2022

The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity

por Song, Edward Z., Wang, Xin, Philipson, Benjamin I., Zhang, Qian, Thokala, Radhika, Zhang, Logan, Assenmacher, Charles-Antoine, Binder, Zev A., Ming, Guo-li, O’Rourke, Donald M., Song, Hongjun, Milone, Michael C.
Publicado 2022

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

por O’Connor, Roddy S., Guo, Lili, Ghassemi, Saba, Snyder, Nathaniel W., Worth, Andrew J., Weng, Liwei, Kam, Yoonseok, Philipson, Benjamin, Trefely, Sophie, Nunez-Cruz, Selene, Blair, Ian A., June, Carl H., Milone, Michael C.
Publicado 2018

CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

por Garcia-Canaveras, Juan C., Heo, David, Trefely, Sophie, Leferovich, John, Xu, Chong, Philipson, Benjamin I., Ghassemi, Saba, Milone, Michael C., Moon, Edmund K., Snyder, Nathaniel W., June, Carl H., Rabinowitz, Joshua D., O’Connor, Roddy S.
Publicado 2021

CD38 as a pan-hematologic target for chimeric antigen receptor T cells

por Glisovic-Aplenc, Tina, Diorio, Caroline, Chukinas, John A., Veliz, Kimberly, Shestova, Olga, Shen, Feng, Nunez-Cruz, Selene, Vincent, Tiffaney L., Miao, Fei, Milone, Michael C., June, Carl H., Teachey, David T., Tasian, Sarah K., Aplenc, Richard, Gill, Saar
Publicado 2023

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

por Ghassemi, Saba, Martinez-Becerra, Francisco J., Master, Alyssa M., Richman, Sarah A., Heo, David, Leferovich, John, Tu, Yitao, García-Cañaveras, Juan Carlos, Ayari, Asma, Lu, Yinan, Wang, Ai, Rabinowitz, Joshua D., Milone, Michael C., June, Carl H., O’Connor, Roddy S.
Publicado 2020

Rapid manufacturing of non-activated potent CAR T cells

por Ghassemi, Saba, Durgin, Joseph S., Nunez-Cruz, Selene, Patel, Jai, Leferovich, John, Pinzone, Marilia, Shen, Feng, Cummins, Katherine D., Plesa, Gabriela, Cantu, Vito Adrian, Reddy, Shantan, Bushman, Frederic D., Gill, Saar I., O’Doherty, Una, O’Connor, Roddy S., Milone, Michael C.
Publicado 2022

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

por Oh, Sangwook, Mao, Xuming, Manfredo-Vieira, Silvio, Lee, Jinmin, Patel, Darshil, Choi, Eun Jung, Alvarado, Andrea, Cottman-Thomas, Ebony, Maseda, Damian, Tsao, Patricia Y., Ellebrecht, Christoph T., Khella, Sami L., Richman, David P., O’Connor, Kevin C., Herzberg, Uri, Binder, Gwendolyn K., Milone, Michael C., Basu, Samik, Payne, Aimee S.
Publicado 2023

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial

por Abella, Benjamin S., Jolkovsky, Eliana L., Biney, Barbara T., Uspal, Julie E., Hyman, Matthew C., Frank, Ian, Hensley, Scott E., Gill, Saar, Vogl, Dan T., Maillard, Ivan, Babushok, Daria V., Huang, Alexander C., Nasta, Sunita D., Walsh, Jennifer C., Wiletyo, E. Paul, Gimotty, Phyllis A., Milone, Michael C., Amaravadi, Ravi K.
Publicado 2020

Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4

por Bhoj, Vijay G., Li, Lucy, Parvathaneni, Kalpana, Zhang, Zheng, Kacir, Stephen, Arhontoulis, Dimitrios, Zhou, Kenneth, McGettigan-Croce, Bevin, Nunez-Cruz, Selene, Gulendran, Gayathri, Boesteanu, Alina C., Johnson, Laura, Feldman, Michael D., Radaelli, Enrico, Mansfield, Keith, Nasrallah, MacLean, Goydel, Rebecca S., Peng, Haiyong, Rader, Christoph, Milone, Michael C., Siegel, Don L.
Publicado 2021

Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma

por Bu, De-Xiu, Singh, Reshma, Choi, Eugene E., Ruella, Marco, Nunez-Cruz, Selene, Mansfield, Keith G., Bennett, Paul, Barton, Nathanial, Wu, Qilong, Zhang, Jiquan, Wang, Yongqiang, Wei, Lai, Cogan, Shawn, Ezell, Tucker, Joshi, Shree, Latimer, Kellie J., Granda, Brian, Tschantz, William R., Young, Regina M., Huet, Heather A., Richardson, Celeste J., Milone, Michael C.
Publicado 2018

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

por Zhang, Hongru, Yu, Pengfei, Tomar, Vivek S., Chen, Xiangjie, Atherton, Matthew J., Lu, Zhen, Zhang, Hong-Guang, Li, Shifeng, Ortiz, Angelica, Gui, Jun, Leu, N. Adrian, Yan, Fangxue, Blanco, Andres, Meyer-Ficca, Mirella L., Meyer, Ralph G., Beiting, Daniel P., Li, Jinyang, Nunez-Cruz, Selene, O’Connor, Roddy S., Johnson, Lexus R., Minn, Andy J., George, Subin S., Koumenis, Constantinos, Diehl, J. Alan, Milone, Michael C., Zheng, Hui, Fuchs, Serge Y.
Publicado 2022

Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy

por Garfall, Alfred L., Cohen, Adam D., Susanibar-Adaniya, Sandra P., Hwang, Wei-Ting, Vogl, Dan T., Waxman, Adam J., Lacey, Simon F., Gonzalez, Vanessa E., Fraietta, Joseph A., Gupta, Minnal, Kulikovskaya, Irina, Tian, Lifeng, Chen, Fang, Koterba, Natalka, Bartoszek, Robert L., Patchin, Margaret, Xu, Rong, Plesa, Gabriela, Siegel, Don L., Brennan, Andrea, Nelson, Anne Marie, Ferthio, Regina, Cosey, Angela, Shea, Kim-Marie, Leskowitz, Rachel, Four, Megan, Wilson, Wesley V., Miao, Fei, Lancaster, Eric, Carreno, Beatriz M., Linette, Gerald P., Hexner, Elizabeth O., Young, Regina M., Bu, Dexiu, Mansfield, Keith G., Brogdon, Jennifer L., June, Carl H., Milone, Michael C., Stadtmauer, Edward A.
Publicado 2023