Hematopoietic stem cell aging and leukemia transformation

por Colom Díaz, Patricia A., Mistry, Jayna J., Trowbridge, Jennifer J.
Publicado 2023

Venetoclax and Daratumumab combination treatment demonstrates pre-clinical efficacy in mouse models of Acute Myeloid Leukemia

por Mistry, Jayna J, Hellmich, Charlotte, Lambert, Amelia, Moore, Jamie A, Jibril, Aisha, Collins, Angela, Bowles, Kristian M, Rushworth, Stuart A
Publicado 2021

S100P enhances the motility and invasion of human trophoblast cell lines

por Tabrizi, Maral E. A., Lancaster, Tara L., Ismail, Thamir M., Georgiadou, Athina, Ganguly, Ankana, Mistry, Jayna J., Wang, Keqing, Rudland, Philip S., Ahmad, Shakil, Gross, Stephane R.
Publicado 2018

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

por Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Publicado 2021

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy

por SanMiguel, Jennifer M., Eudy, Elizabeth, Loberg, Matthew A., Miles, Linde A., Stearns, Tim, Mistry, Jayna J., Rauh, Michael J., Levine, Ross L., Trowbridge, Jennifer J.
Publicado 2022

PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma

por Kumar, Prakrit R., Saad, Mona, Hellmich, Charlotte, Mistry, Jayna J., Moore, Jamie A., Conway, Shannon, Morris, Christopher J., Bowles, Kristian M., Moncrieff, Marc D., Rushworth, Stuart A.
Publicado 2022

p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

por Hellmich, Charlotte, Wojtowicz, Edyta, Moore, Jamie A., Mistry, Jayna J., Jibril, Aisha, Johnson, Benjamin B., Smith, James G. W., Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Publicado 2022

Daratumumab inhibits acute myeloid leukemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells

por Mistry, Jayna J., Moore, Jamie A., Kumar, Prakrit, Marlein, Christopher R., Hellmich, Charlotte, Pillinger, Genevra, Jibril, Aisha, Di Palma, Federica, Collins, Angela, Bowles, Kristian M., Rushworth, Stuart A
Publicado 2020

LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation

por Moore, Jamie A., Mistry, Jayna J., Hellmich, Charlotte, Horton, Rebecca H., Wojtowicz, Edyta E., Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Publicado 2022

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

por SanMiguel, Jennifer M., Eudy, Elizabeth, Loberg, Matthew A., Young, Kira A., Mistry, Jayna J., Mujica, Kristina D., Schwartz, Logan S., Stearns, Timothy M., Challen, Grant A., Trowbridge, Jennifer J.
Publicado 2022

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

por Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Publicado 2019

Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion

por Wojtowicz, Edyta E., Mistry, Jayna J., Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W., Kettyle, Laura M., Grasso, Francesca, Lord, Allegra M., Wright, David J., Etherington, Graham J., Woll, Petter S., Belderbos, Mirjam E., Bowles, Kristian M., Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V., Jacobsen, Sten Eirik W., Rushworth, Stuart A., Macaulay, Iain C.
Publicado 2023