Ocular therapies for neuronal ceroid lipofuscinoses: more than meets the eye

por Murray, Samantha J., Mitchell, Nadia L.
Publicado 2022

The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders

por Murray, Samantha J., Mitchell, Nadia L.
Publicado 2022

Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses

por Russell, Katharina N., Mitchell, Nadia L., Wellby, Martin P., Barrell, Graham K., Palmer, David N.
Publicado 2021

The development of brain magnetic resonance approaches in large animal models for preclinical research

por Ella, Arsène, Barrière, David A, Adriaensen, Hans, Palmer, David N, Melzer, Tracy R, Mitchell, Nadia L, Keller, Matthieu
Publicado 2019

Molecular neuropathology of the synapse in sheep with CLN5 Batten disease

por Amorim, Inês S., Mitchell, Nadia L., Palmer, David N., Sawiak, Stephen J., Mason, Roger, Wishart, Thomas M., Gillingwater, Thomas H.
Publicado 2015

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep

por Perentos, Nicholas, Martins, Amadeu Q., Watson, Thomas C., Bartsch, Ullrich, Mitchell, Nadia L., Palmer, David N., Jones, Matthew W., Morton, A. Jennifer
Publicado 2015

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ce...

por Russell, Katharina N., Mitchell, Nadia L., Anderson, Nigel G., Bunt, Craig R., Wellby, Martin P., Melzer, Tracy R., Barrell, Graham K., Palmer, David N.
Publicado 2018

Efficacy of dual intracerebroventricular and intravitreal CLN5 gene therapy in sheep prompts the first clinical trial to treat CLN5 Batten disease

por Murray, Samantha J., Wellby, Martin P., Barrell, Graham K., Russell, Katharina N., Deane, Ashley R., Wynyard, John R., Gray, Steven J., Palmer, David N., Mitchell, Nadia L.
Publicado 2023

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

por Sawiak, Stephen J., Perumal, Sunthara Rajan, Rudiger, Skye R., Matthews, Loren, Mitchell, Nadia L., McLaughlan, Clive J., Bawden, C. Simon, Palmer, David N., Kuchel, Timothy, Morton, A. Jennifer
Publicado 2015

Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis

por Murray, Samantha J, Almuqbel, Mustafa M, Felton, Simon A, Palmer, Nickolas J, Myall, Daniel J, Shoorangiz, Reza, Ella, Arsène, Keller, Matthieu, Palmer, David N, Melzer, Tracy R, Mitchell, Nadia L
Publicado 2023

Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease

por Mitchell, Nadia L., Murray, Samantha J., Wellby, Martin P., Barrell, Graham K., Russell, Katharina N., Deane, Ashley R., Wynyard, John R., Palmer, Madeleine J., Pulickan, Anila, Prendergast, Phillipa M., Casy, Widler, Gray, Steven J., Palmer, David N.
Publicado 2023

Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC

por O’Leary, Claire, Forte, Gabriella, Mitchell, Nadia L., Youshani, Amir Saam, Dyer, Adam, Wellby, Martin P., Russell, Katharina N., Murray, Samantha J., Jolinon, Nelly, Jones, Simon A, Stacey, Kevin, Davis, Daniel M., Henckaerts, Els, Palmer, David N., Kamaly-Asl, Ian, Bigger, Brian W.
Publicado 2023

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

por Eaton, Samantha L., Murdoch, Fraser, Rzechorzek, Nina M., Thompson, Gerard, Hartley, Claudia, Blacklock, Benjamin Thomas, Proudfoot, Chris, Lillico, Simon G., Tennant, Peter, Ritchie, Adrian, Nixon, James, Brennan, Paul M., Guido, Stefano, Mitchell, Nadia L., Palmer, David N., Whitelaw, C. Bruce A., Cooper, Jonathan D., Wishart, Thomas M.
Publicado 2022