What Is the Significance of Lysosomal-Mediated Resistance to Imatinib?

por Mlejnek, Petr
Publicado 2023

Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection

por Mlejnek, Petr
Publicado 2022

Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis

por Skoupa, Nikola, Dolezel, Petr, Mlejnek, Petr
Publicado 2020

Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transpo...

por Pastvova, Nikola, Dolezel, Petr, Mlejnek, Petr
Publicado 2021

Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in...

por Skoupa, Nikola, Dolezel, Petr, Ruzickova, Eliska, Mlejnek, Petr
Publicado 2017

N-acetylcysteine Can Induce Massive Oxidative Stress, Resulting in Cell Death with Apoptotic Features in Human Leukemia Cells

por Mlejnek, Petr, Dolezel, Petr, Kriegova, Eva, Pastvova, Nikola
Publicado 2021

The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

por Ruzickova, Eliska, Skoupa, Nikola, Dolezel, Petr, Smith, Dennis A., Mlejnek, Petr
Publicado 2019

Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension

por Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Kubovčiak, Jan, Sticová, Eva, Pravenec, Michal
Publicado 2022

Microarray and qPCR Analysis of Mitochondrial Metabolism Activation during Prenatal and Early Postnatal Development in Rats and Humans with Emphasis on CoQ(10) Biosynthesis

por Krizova, Jana, Hulkova, Martina, Capek, Vaclav, Mlejnek, Petr, Silhavy, Jan, Tesarova, Marketa, Zeman, Jiri, Hansikova, Hana
Publicado 2021

CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study

por Silhavy, Jan, Mlejnek, Petr, Šimáková, Miroslava, Marková, Irena, Malínská, Hana, Hüttl, Martina, Kazdová, Ludmila, Kazantsev, Dmitry, Mancini, Massimiliano, Novotný, Jiří, Pravenec, Michal
Publicado 2023

Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats

por Šilhavý, Jan, Zídek, Václav, Mlejnek, Petr, Landa, Vladimír, Šimáková, Miroslava, Strnad, Hynek, Oliyarnyk, Olena, Škop, Vojtěch, Kazdová, Ludmila, Kurtz, Theodore, Pravenec, Michal
Publicado 2014

Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

por Malínská, Hana, Oliyarnyk, Olena, Škop, Vojtěch, Šilhavý, Jan, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Kazdová, Ludmila, Pravenec, Michal
Publicado 2016

Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

por Šilhavý, Jan, Malínská, Hana, Hüttl, Martina, Marková, Irena, Oliyarnyk, Olena, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Kazdová, Ludmila, Moravcová, Radka, Novotný, Jiří, Pravenec, Michal
Publicado 2020

Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

por Malínská, Hana, Hüttl, Martina, Marková, Irena, Miklánková, Denisa, Hojná, Silvie, Papoušek, František, Šilhavý, Jan, Mlejnek, Petr, Zicha, Josef, Hrdlička, Jaroslav, Pravenec, Michal, Vaněčková, Ivana
Publicado 2022

Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome

por Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Malínská, Hana, Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Kazdová, Ludmila, Vrbacký, Marek, Pecinová, Alena, Mráček, Tomáš, Pravenec, Michal
Publicado 2023

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue...

por Trnovská, Jaroslava, Šilhavý, Jan, Kuda, Ondřej, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Škop, Vojtěch, Oliyarnyk, Olena, Kazdová, Ludmila, Haluzík, Martin, Pravenec, Michal
Publicado 2017

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

por Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Pravenec, Michal
Publicado 2016

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

por Rýdlová, Michaela, Růnová, Karolína, Száková, Jiřina, Fučíková, Alena, Hakenová, Anna, Mlejnek, Petr, Zídek, Václav, Tremlová, Jana, Mestek, Oto, Kaňa, Antonín, Zídková, Jarmila, Melčová, Magdalena, Truhlářová, Klára, Tlustoš, Pavel
Publicado 2017

Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

por Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Pravenec, Michal
Publicado 2020

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

por Senko, Anna N., Overall, Rupert W., Silhavy, Jan, Mlejnek, Petr, Malínská, Hana, Hüttl, Martina, Marková, Irena, Fabel, Klaus S., Lu, Lu, Stuchlik, Ales, Williams, Robert W., Pravenec, Michal, Kempermann, Gerd
Publicado 2022