Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

por Chen, Xu-Qiao, Mobley, William C.
Publicado 2019

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

por Chen, Xu-Qiao, Mobley, William C.
Publicado 2019

Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome

por Do, Long H., Mobley, William C., Singhal, Nishant
Publicado 2015

Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

por Chen, Xu-Qiao, Das, Utpal, Park, Gooho, Mobley, William C.
Publicado 2021

Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome

por Takahashi, Tatsunori, Sakai, Noriaki, Iwasaki, Tomonori, Doyle, Timothy C., Mobley, William C., Nishino, Seiji
Publicado 2020

Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons

por Schairer, Cynthia E., Tutjer, Jenna, Cannavino, Christopher, Mobley, William C., Eyler, Lisa, Bloss, Cinnamon S.
Publicado 2022

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

por Belichenko, Pavel V., Kleschevnikov, Alexander M., Becker, Ann, Wagner, Grant E., Lysenko, Larisa V., Yu, Y. Eugene, Mobley, William C.
Publicado 2015

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer’s disease biomarkers in down syndrome

por Rafii, Michael S., Wishnek, Hannah, Brewer, James B., Donohue, Michael C., Ness, Seth, Mobley, William C., Aisen, Paul S., Rissman, Robert A.
Publicado 2015

Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model

por Chen, Xu‐Qiao, Salehi, Ahmad, Pearn, Matthew L., Overk, Cassia, Nguyen, Phuong D., Kleschevnikov, Alexander M., Maccecchini, Maria, Mobley, William C.
Publicado 2020

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome

por Chen, Xu-Qiao, Xing, Zhuo, Chen, Quang-Di, Salvi, Richard J., Zhang, Xuming, Tycko, Benjamin, Mobley, William C., Yu, Y. Eugene
Publicado 2021

Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous...

por Villoslada, Pablo, Hauser, Stephen L., Bartke, Ilse, Unger, Jurgen, Heald, Nathan, Rosenberg, Daniel, Cheung, Steven W., Mobley, William C., Fisher, Stefan, Genain, Claude P.
Publicado 2000

Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

por Overk, Cassia, Fiorini, Emma, Babolin, Chiara, Vukicevic, Marija, Morici, Catherine, Madani, Rime, Eligert, Valerie, Kosco-Vilbois, Marie, Roberts, Amanda, Becker, Ann, Pfeifer, Andrea, Mobley, William C.
Publicado 2023

Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease

por Valdes, Phoebe, Henry, Kenneth W., Fitzgerald, Michael Q., Muralidharan, Koushik, Caldwell, Andrew B., Ramachandran, Srinivasan, Goldstein, Lawrence S. B., Mobley, William C., Galasko, Douglas R., Subramaniam, Shankar
Publicado 2023

A novel mechanism underlying pathogenesis of Down syndrome

por Wang, Xin, Zhao, Yingjun, Zhang, Xiaofei, Zhou, Ying, Ranscht, Barbara, Gage, Fred H, Mobley, William C, Zhang, Yun-wu, Lipton, Stuart A, Hong, Wanjin, Xu, Huaxi
Publicado 2013

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β...

por Wagner, Steven L., Zhang, Can, Cheng, Soan, Nguyen, Phuong, Zhang, Xulun, Rynearson, Kevin D., Wang, Rong, Li, Yueming, Sisodia, Sangram S., Mobley, William C., Tanzi, Rudolph E.
Publicado 2014

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

por Moya-Alvarado, Guillermo, Tiburcio-Felix, Reynaldo, Ibáñez, María Raquel, Aguirre-Soto, Alejandro A, Guerra, Miguel V, Wu, Chengbiao, Mobley, William C, Perlson, Eran, Bronfman, Francisca C
Publicado 2023

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP

por Weissmiller, April M., Natera-Naranjo, Orlangie, Reyna, Sol M., Pearn, Matthew L., Zhao, Xiaobei, Nguyen, Phuong, Cheng, Soan, Goldstein, Lawrence S. B., Tanzi, Rudolph E., Wagner, Steven L., Mobley, William C., Wu, Chengbiao
Publicado 2015

Dissociation of Down syndrome and Alzheimer's disease effects with imaging

por Matthews, Dawn C., Lukic, Ana S., Andrews, Randolph D., Marendic, Boris, Brewer, James, Rissman, Robert A., Mosconi, Lisa, Strother, Stephen C., Wernick, Miles N., Mobley, William C., Ness, Seth, Schmidt, Mark E., Rafii, Michael S.
Publicado 2016

Reversing Parkinson Disease Model with in situ Converted Nigral Neurons

por Qian, Hao, Kang, Xinjiang, Hu, Jing, Zhang, Dongyang, Liang, Zhengyu, Meng, Fan, Zhang, Xuan, Xue, Yuanchao, Maimon, Roy, Dowdy, Steven F., Devaraj, Neal K., Zhou, Zhuan, Mobley, William C., Cleveland, Don W., Fu, Xiang-Dong
Publicado 2020

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

por Wagner, Steven L., Rynearson, Kevin D., Duddy, Steven K., Zhang, Can, Nguyen, Phuong D., Becker, Ann, Vo, Uyen, Masliah, Deborah, Monte, Louise, Klee, Justin B., Echmalian, Corinne M., Xia, Weiming, Quinti, Luisa, Johnson, Graham, Lin, Jiunn H., Kim, Doo Y., Mobley, William C., Rissman, Robert A., Tanzi, Rudolph E.
Publicado 2017