The Case for a Novel Therapeutic Approach to Dementia: Small Molecule Hepatocyte Growth Factor (HGF/MET) Positive Modulators

por Moebius, Hans J., Church, Kevin J.
Publicado 2023

Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential

por Olichney, John, Xia, Jiangyi, Church, Kevin J., Moebius, Hans J.
Publicado 2022

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer’s Disease: Random...

por Hua, Xue, Church, Kevin, Walker, William, L’Hostis, Philippe, Viardot, Geoffrey, Danjou, Philippe, Hendrix, Suzanne, Moebius, Hans J.
Publicado 2022

Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia

por Keefe, Richard SE, Meltzer, Herbert A, Dgetluck, Nancy, Gawryl, Maria, Koenig, Gerhard, Moebius, Hans J, Lombardo, Ilise, Hilt, Dana C
Publicado 2015

A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus

por Suckfüll, Markus, Althaus, Michael, Ellers-Lenz, Barbara, Gebauer, Alexander, Görtelmeyer, Roman, Jastreboff, Pawel J, Moebius, Hans J, Rosenberg, Tanja, Russ, Hermann, Wirth, Yvonne, Krueger, Hagen
Publicado 2011

Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia

por Johnston, Jewel L., Reda, Sherif M., Setti, Sharay E., Taylor, Robert W., Berthiaume, Andrée-Anne, Walker, William E., Wu, Wei, Moebius, Hans J., Church, Kevin J.
Publicado 2022

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome i...

por Wilcock, Gordon K., Gauthier, Serge, Frisoni, Giovanni B., Jia, Jianping, Hardlund, Jiri H., Moebius, Hans J., Bentham, Peter, Kook, Karin A., Schelter, Bjoern O., Wischik, Damon J., Davis, Charles S., Staff, Roger T., Vuksanovic, Vesna, Ahearn, Trevor, Bracoud, Luc, Shamsi, Kohkan, Marek, Ken, Seibyl, John, Riedel, Gernot, Storey, John M.D., Harrington, Charles R., Wischik, Claude M.
Publicado 2017

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

por Shiells, Helen, Schelter, Bjoern O., Bentham, Peter, Baddeley, Thomas C., Rubino, Christopher M., Ganesan, Harish, Hammel, Jeffrey, Vuksanovic, Vesna, Staff, Roger T., Murray, Alison D., Bracoud, Luc, Wischik, Damon J., Riedel, Gernot, Gauthier, Serge, Jia, Jianping, Moebius, Hans J., Hardlund, Jiri, Kipps, Christopher M., Kook, Karin, Storey, John M.D., Harrington, Charles R., Wischik, Claude M.
Publicado 2020

Diagnostic criteria for apathy in neurocognitive disorders

por Miller, David S., Robert, Philippe, Ereshefsky, Larry, Adler, Lawrence, Bateman, Daniel, Cummings, Jeff, DeKosky, Steven T., Fischer, Corinne E., Husain, Masud, Ismail, Zahinoor, Jaeger, Judith, Lerner, Alan J., Li, Abby, Lyketsos, Constantine G., Manera, Valeria, Mintzer, Jacobo, Moebius, Hans J., Mortby, Moyra, Meulien, Didier, Pollentier, Stephane, Porsteinsson, Anton, Rasmussen, Jill, Rosenberg, Paul B., Ruthirakuhan, Myuri T., Sano, Mary, Zucchero Sarracini, Carla, Lanctôt, Krista L.
Publicado 2021