The emerging determinants of replication fork stability

por Thakar, Tanay, Moldovan, George-Lucian
Publicado 2021

Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment

por Jackson, Lindsey M, Moldovan, George-Lucian
Publicado 2022

The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1

por Dhoonmoon, Ashna, Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA

por Leung, Wendy, Baxley, Ryan M., Moldovan, George-Lucian, Bielinsky, Anja-Katrin
Publicado 2018

Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases

por Hale, Anastasia, Dhoonmoon, Ashna, Straka, Joshua, Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2023

The Integrated Holistic Security and Privacy Framework Deployed in CrowdHEALTH Project

por Malliaros, Stefanos, Xenakis, Christos, Moldovan, George, Mantas, John, Magdalinou, Andriana, Montandon, Lydia
Publicado 2019

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

por Dhoonmoon, Ashna, Schleicher, Emily M, Clements, Kristen E, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2020

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

por Arakawa, Hiroshi, Moldovan, George-Lucian, Saribasak, Huseyin, Saribasak, Nesibe Nur, Jentsch, Stefan, Buerstedde, Jean-Marie
Publicado 2006

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

por Schleicher, Emily M, Galvan, Adri M, Imamura-Kawasawa, Yuka, Moldovan, George-Lucian, Nicolae, Claudia M
Publicado 2018

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

por Thakar, Tanay, Dhoonmoon, Ashna, Straka, Joshua, Schleicher, Emily M., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

por Clements, Kristen E, Thakar, Tanay, Nicolae, Claudia M, Liang, Xinwen, Wang, Hong-Gang, Moldovan, George-Lucian
Publicado 2018

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Khatib, Jude B., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival

por Khatib, Jude B., Schleicher, Emily M., Jackson, Lindsey M., Dhoonmoon, Ashna, Moldovan, George-Lucian, Nicolae, Claudia M.
Publicado 2022

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

por Thakar, Tanay, Leung, Wendy, Nicolae, Claudia M., Clements, Kristen E., Shen, Binghui, Bielinsky, Anja-Katrin, Moldovan, George-Lucian
Publicado 2020

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells

por Jackson, Lindsey M, Dhoonmoon, Ashna, Hale, Anastasia, Dennis, Kady A, Schleicher, Emily M, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2021

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2020

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

por Nicolae, Claudia M., Aho, Erin R., Choe, Katherine N., Constantin, Daniel, Hu, He-Juan, Lee, Deokjae, Myung, Kyungjae, Moldovan, George-Lucian
Publicado 2015

Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium‐dependent, non‐D(2) receptor‐dependent, manner

por Weissenrieder, Jillian S., Reed, Jessie L., Moldovan, George‐Lucian, Johnson, Martin T., Trebak, Mohamed, Neighbors, Jeffrey D., Mailman, Richard B., Hohl, Raymond J.
Publicado 2021

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

por Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Publicado 2021

The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1

por Hirschler-Laszkiewicz, Iwona, Festa, Fernanda, Huang, Suming, Moldovan, George-Lucian, Nicolae, Claudia, Dhoonmoon, Ashna, Bao, Lei, Keefer, Kerry, Chen, Shu-jen, Wang, Hong-Gang, Cheung, Joseph Y., Miller, Barbara A.
Publicado 2022