Drugging the Undruggable: Advances on RAS Targeting in Cancer

por Molina-Arcas, Miriam, Samani, Amit, Downward, Julian
Publicado 2021

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

por Castellano, Esther, Molina-Arcas, Miriam, Krygowska, Agata Adelajda, East, Philip, Warne, Patricia, Nicol, Alastair, Downward, Julian
Publicado 2016

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

por Steckel, Michael, Molina-Arcas, Miriam, Weigelt, Britta, Marani, Michaela, Warne, Patricia H, Kuznetsov, Hanna, Kelly, Gavin, Saunders, Becky, Howell, Michael, Downward, Julian, Hancock, David C
Publicado 2012

Therapeutic KRAS(G12C) inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

por Mugarza, Edurne, van Maldegem, Febe, Boumelha, Jesse, Moore, Christopher, Rana, Sareena, Llorian Sopena, Miriam, East, Philip, Ambler, Rachel, Anastasiou, Panayiotis, Romero-Clavijo, Pablo, Valand, Karishma, Cole, Megan, Molina-Arcas, Miriam, Downward, Julian
Publicado 2022

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

por Coelho, Matthew A., de Carné Trécesson, Sophie, Rana, Sareena, Zecchin, Davide, Moore, Christopher, Molina-Arcas, Miriam, East, Philip, Spencer-Dene, Bradley, Nye, Emma, Barnouin, Karin, Snijders, Ambrosius P., Lai, Wi S., Blackshear, Perry J., Downward, Julian
Publicado 2017

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

por Jones, Greg G., del Río, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C., Hartig, Nicole, Areso Zubiaur, Itziar, El-Bahrawy, Mona A., Hynds, Rob E., Lei, Winnie, Molina-Arcas, Miriam, Downward, Julian, Rodriguez-Viciana, Pablo
Publicado 2019

RAC1(P29S) Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

por Lionarons, Daniël A., Hancock, David C., Rana, Sareena, East, Philip, Moore, Christopher, Murillo, Miguel M., Carvalho, Joana, Spencer-Dene, Bradley, Herbert, Eleanor, Stamp, Gordon, Damry, Djamil, Calado, Dinis P., Rosewell, Ian, Fritsch, Ralph, Neubig, Richard R., Molina-Arcas, Miriam, Downward, Julian
Publicado 2019

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

por van Maldegem, Febe, Valand, Karishma, Cole, Megan, Patel, Harshil, Angelova, Mihaela, Rana, Sareena, Colliver, Emma, Enfield, Katey, Bah, Nourdine, Kelly, Gavin, Tsang, Victoria Siu Kwan, Mugarza, Edurne, Moore, Christopher, Hobson, Philip, Levi, Dina, Molina-Arcas, Miriam, Swanton, Charles, Downward, Julian
Publicado 2021

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

por Ismail, Mohamed, Martin, Stephen R., George, Roger, Houghton, Francesca, Kelly, Geoff, Chaleil, Raphaël A. G., Anastasiou, Panayiotis, Wang, Xinyue, O’Reilly, Nicola, Federico, Stefania, Joshi, Dhira, Nagaraj, Hemavathi, Cooley, Rachel, Hui, Ning Sze, Molina-Arcas, Miriam, Hancock, David C., Tavassoli, Ali, Downward, Julian
Publicado 2023

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

por Wamaitha, Sissy E., Grybel, Katarzyna J., Alanis-Lobato, Gregorio, Gerri, Claudia, Ogushi, Sugako, McCarthy, Afshan, Mahadevaiah, Shantha K., Healy, Lyn, Lea, Rebecca A., Molina-Arcas, Miriam, Devito, Liani G., Elder, Kay, Snell, Phil, Christie, Leila, Downward, Julian, Turner, James M. A., Niakan, Kathy K.
Publicado 2020

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

por Ng, Kevin W., Boumelha, Jesse, Enfield, Katey S. S., Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A., Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T. C., Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R. M., Watkins, Thomas B. K., Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M., Al Bakir, Maise, Lim, Emilia L., Hill, Mark S., Wilson, Gareth A., Cook, Daniel E., Birkbak, Nicolai J., Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T., Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George
Publicado 2023