A sting in the tail: the N-terminal domain of the androgen receptor as a drug target

por Monaghan, Amy E, McEwan, Iain J
Publicado 2016

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants

por Monaghan, Amy E., Porter, Alison, Hunter, Irene., Morrison, Angus, McElroy, Stuart P., McEwan, Iain J.
Publicado 2022

Structural Insights into Notum Covalent Inhibition

por Zhao, Yuguang, Svensson, Fredrik, Steadman, David, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Moreira, Tiago, Chalk, Rod, Lu, Weixian, Fish, Paul V., Jones, E. Yvonne
Publicado 2021

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

por Atkinson, Benjamin N., Steadman, David, Zhao, Yuguang, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Jeganathan, Fiona, Lines, Georgie, Frew, Sarah, Monaghan, Amy, Kjær, Svend, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Publicado 2019

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

por Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Publicado 2020

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

por Atilano, Magda L, Grönke, Sebastian, Niccoli, Teresa, Kempthorne, Liam, Hahn, Oliver, Morón-Oset, Javier, Hendrich, Oliver, Dyson, Miranda, Adams, Mirjam Lisette, Hull, Alexander, Salcher-Konrad, Marie-Therese, Monaghan, Amy, Bictash, Magda, Glaria, Idoia, Isaacs, Adrian M, Partridge, Linda
Publicado 2021

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

por Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.
Publicado 2022

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci

por Soutar, Marc P M, Melandri, Daniela, O’Callaghan, Benjamin, Annuario, Emily, Monaghan, Amy E, Welsh, Natalie J, D’Sa, Karishma, Guelfi, Sebastian, Zhang, David, Pittman, Alan, Trabzuni, Daniah, Verboven, Anouk H A, Pan, Kylie S, Kia, Demis A, Bictash, Magda, Gandhi, Sonia, Houlden, Henry, Cookson, Mark R, Kasri, Nael Nadif, Wood, Nicholas W, Singleton, Andrew B, Hardy, John, Whiting, Paul J, Blauwendraat, Cornelis, Whitworth, Alexander J, Manzoni, Claudia, Ryten, Mina, Lewis, Patrick A, Plun-Favreau, Hélène
Publicado 2022