Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

por Gordon, David, Hellriegel, Edward T, Hope, Heidi Rath, Burt, David, Monahan, Joseph B
Publicado 2021

Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis

por Gordon, David, Kivitz, Alan, Singhal, Atul, Burt, David, Bangs, Madison C., Huff, Emma E., Hope, Heidi Rath, Monahan, Joseph B.
Publicado 2023

Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

por Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L., Monahan, Joseph B., Veis, Deborah J., Abu-Amer, Yousef, Link, Daniel C., Mbalaviele, Gabriel
Publicado 2020

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

por Wang, Chun, Hockerman, Susan, Jacobsen, E. Jon, Alippe, Yael, Selness, Shaun R., Hope, Heidi R., Hirsch, Jeffrey L., Mnich, Stephen J., Saabye, Matthew J., Hood, William F., Bonar, Sheri L., Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M., Monahan, Joseph B., Mbalaviele, Gabriel
Publicado 2018