Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases

por Monk, Brian C., Keniya, Mikhail V.
Publicado 2021

Correction: Monk, B.C.; Keniya, M.V. Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases. J. Fungi 2021, 7, 67

por Monk, Brian C., Keniya, Mikhail V.
Publicado 2021

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

por Rosam, Katharina, Monk, Brian C., Lackner, Michaela
Publicado 2020

Exploring Cryptococcus neoformans CYP51 and Its Cognate Reductase as a Drug Target

por Ruma, Yasmeen N., Keniya, Mikhail V., Monk, Brian C.
Publicado 2022

Functional Expression of Recombinant Candida auris Proteins in Saccharomyces cerevisiae Enables Azole Susceptibility Evaluation and Drug Discovery

por Toepfer, Stephanie, Lackner, Michaela, Keniya, Mikhail V., Monk, Brian C.
Publicado 2023

Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance

por Keniya, Mikhail V., Fleischer, Edmond, Klinger, Anette, Cannon, Richard D., Monk, Brian C.
Publicado 2015

Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

por Banerjee, Atanu, Pata, Jorgaq, Sharma, Suman, Monk, Brian C., Falson, Pierre, Prasad, Rajendra
Publicado 2021

Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host

por Ruma, Yasmeen N., Keniya, Mikhail V., Tyndall, Joel D. A., Monk, Brian C.
Publicado 2022

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase

por Caramalho, Rita, Tyndall, Joel D. A., Monk, Brian C., Larentis, Thomas, Lass-Flörl, Cornelia, Lackner, Michaela
Publicado 2017

Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris

por Toepfer, Stephanie, Lackner, Michaela, Keniya, Mikhail V., Zenz, Lisa-Maria, Friemert, Marianne, Bracher, Franz, Monk, Brian C.
Publicado 2023

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

por Sagatova, Alia A., Keniya, Mikhail V., Wilson, Rajni K., Sabherwal, Manya, Tyndall, Joel D. A., Monk, Brian C.
Publicado 2016

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate

por Graham, Danyon O., Wilson, Rajni K., Ruma, Yasmeen N., Keniya, Mikhail V., Tyndall, Joel D. A., Monk, Brian C.
Publicado 2021

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

por Tyndall, Joel D. A., Sabherwal, Manya, Sagatova, Alia A., Keniya, Mikhail V., Negroni, Jacopo, Wilson, Rajni K., Woods, Matthew A., Tietjen, Klaus, Monk, Brian C.
Publicado 2016

[Fe(2)L(3)](4+) Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole “Click” Ligands: Synthesis, Structures and Exploration of Biological Activity

por Vellas, Sreedhar K., Lewis, James E. M., Shankar, Madhu, Sagatova, Alia, Tyndall, Joel D. A., Monk, Brian C., Fitchett, Christopher M., Hanton, Lyall R., Crowley, James D.
Publicado 2013

Highlighting membrane protein structure and function: A celebration of the Protein Data Bank

por Li, Fei, Egea, Pascal F., Vecchio, Alex J., Asial, Ignacio, Gupta, Meghna, Paulino, Joana, Bajaj, Ruchika, Dickinson, Miles Sasha, Ferguson-Miller, Shelagh, Monk, Brian C., Stroud, Robert M.
Publicado 2021

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

por Rawal, Manpreet Kaur, Banerjee, Atanu, Shah, Abdul Haseeb, Khan, Mohammad Firoz, Sen, Sobhan, Saxena, Ajay Kumar, Monk, Brian C., Cannon, Richard D., Bhatnagar, Rakesh, Mondal, Alok Kumar, Prasad, Rajendra
Publicado 2016

Erratum: Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

por Rawal, Manpreet Kaur, Banerjee, Atanu, Shah, Abdul Haseeb, Khan, Mohammad Firoz, Sen, Sobhan, Saxena, Ajay Kumar, Monk, Brian C., Cannon, Richard D., Bhatnagar, Rakesh, Mondal, Alok Kumar, Prasad, Rajendra
Publicado 2016