Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration

por Aquino-Martínez, Rubén, Monroe, David G., Ventura, Francesc
Publicado 2019

Cellular senescence and the skeleton: pathophysiology and therapeutic implications

por Khosla, Sundeep, Farr, Joshua N., Monroe, David G.
Publicado 2022

Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation

por Monroe, David G, Hawse, John R, Subramaniam, Malayannan, Spelsberg, Thomas C
Publicado 2010

Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?

por Aquino-Martinez, Ruben, Khosla, Sundeep, Farr, Joshua N., Monroe, David G.
Publicado 2020

Dissection of Estrogen Receptor Alpha Signaling Pathways in Osteoblasts Using RNA-Sequencing

por Roforth, Matthew M., Atkinson, Elizabeth J., Levin, Ellis R., Khosla, Sundeep, Monroe, David G.
Publicado 2014

MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

por Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.
Publicado 2023

Identification of a suitable endogenous control miRNA in bone aging and senescence

por Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Rowsey, Jennifer L., Vos, Stephanie J., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.
Publicado 2022

ERβ inhibits cyclin dependent kinases 1 and 7 in triple negative breast cancer

por Reese, Jordan M., Bruinsma, Elizabeth S., Monroe, David G., Negron, Vivian, Suman, Vera J., Ingle, James N., Goetz, Matthew P., Hawse, John R.
Publicado 2017

Modulation of fracture healing by the transient accumulation of senescent cells

por Saul, Dominik, Monroe, David G, Rowsey, Jennifer L, Kosinsky, Robyn Laura, Vos, Stephanie J, Doolittle, Madison L, Farr, Joshua N, Khosla, Sundeep
Publicado 2021

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

por Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Publicado 2023

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

por Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Publicado 2023

Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

por Doolittle, Madison L., Eckhardt, Brittany A., Vos, Stephanie J., Grain, Sarah, Rowsey, Jennifer L., Ruan, Ming, Saul, Dominik, Farr, Joshua N., Weivoda, Megan M., Khosla, Sundeep, Monroe, David G.
Publicado 2023

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

por Farr, Joshua N., Roforth, Matthew M., Fujita, Koji, Nicks, Kristy M., Cunningham, Julie M., Atkinson, Elizabeth J., Therneau, Terry M., McCready, Louise K., Peterson, James M., Drake, Matthew T., Monroe, David G., Khosla, Sundeep
Publicado 2015

Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization

por Emch, Michael J., Wicik, Zofia, Aspros, Kirsten G.M., Vukajlovic, Tanja, Pitel, Kevin S., Narum, Anders K., Weivoda, Megan M., Tang, Xiaojia, Kalari, Krishna R., Turner, Russell T., Iwaniec, Urszula T., Monroe, David G., Subramaniam, Malayannan, Hawse, John R.
Publicado 2023

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

por Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep
Publicado 2022

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

por Samakkarnthai, Parinya, Saul, Dominik, Zhang, Lei, Aversa, Zaira, Doolittle, Madison L., Sfeir, Jad G., Kaur, Japneet, Atkinson, Elizabeth J., Edwards, James R., Russell, Graham G., Pignolo, Robert J., Kirkland, James L., Tchkonia, Tamar, Niedernhofer, Laura J., Monroe, David G., Lebrasseur, Nathan K., Farr, Joshua N., Robbins, Paul D., Khosla, Sundeep
Publicado 2023

Targeting cellular senescence prevents age-related bone loss in mice

por Farr, Joshua N., Xu, Ming, Weivoda, Megan M., Monroe, David G., Fraser, Daniel G., Onken, Jennifer L., Negley, Brittany A., Sfeir, Jad G., Ogrodnik, Mikolaj B., Hachfeld, Christine M., LeBrasseur, Nathan K., Drake, Matthew T., Pignolo, Robert J., Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L., Khosla, Sundeep
Publicado 2017

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

por Weivoda, Megan M., Chew, Chee Kian, Monroe, David G., Farr, Joshua N., Atkinson, Elizabeth J., Geske, Jennifer R., Eckhardt, Brittany, Thicke, Brianne, Ruan, Ming, Tweed, Amanda J., McCready, Louise K., Rizza, Robert A., Matveyenko, Aleksey, Kassem, Moustapha, Andersen, Thomas Levin, Vella, Adrian, Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, Khosla, Sundeep
Publicado 2020

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

por Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep
Publicado 2022

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

por Farr, Joshua N., Saul, Dominik, Doolittle, Madison L., Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Froemming, Mitchell N., Lagnado, Anthony B., Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J., Niedernhofer, Laura J., Robbins, Paul D., Jurk, Diana, Passos, João F., LeBrasseur, Nathan K., Tchkonia, Tamara, Kirkland, James L., Monroe, David G., Khosla, Sundeep
Publicado 2023