Contribution of GTPase activity to LRRK2-associated Parkinson disease

por Tsika, Elpida, Moore, Darren J
Publicado 2013

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models

por Dues, Dylan J., Moore, Darren J.
Publicado 2020

LRRK2 and the Endolysosomal System in Parkinson’s Disease

por Erb, Madalynn L., Moore, Darren J.
Publicado 2020

VPS35, the Retromer Complex and Parkinson’s Disease

por Williams, Erin T., Chen, Xi, Moore, Darren J.
Publicado 2017

VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease

por Chen, Xi, Tsika, Elpida, Levine, Nathan, Moore, Darren J.
Publicado 2023

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s disease

por Senchuk, Megan M., Van Raamsdonk, Jeremy M., Moore, Darren J.
Publicado 2021

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction

por Dues, Dylan J., Nguyen, An Phu Tran, Becker, Katelyn, Ma, Jiyan, Moore, Darren J.
Publicado 2023

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction

por Dues, Dylan J., Nguyen, An Phu Tran, Becker, Katelyn, Ma, Jiyan, Moore, Darren J.
Publicado 2023

GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

por Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip J., Glauser, Liliane, West, Andrew B., Moore, Darren J.
Publicado 2012

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2

por Dues, Dylan J., Ma, Yue, Nguyen, An Phu Tran, Offerman, Alina V., Beddows, Ian, Moore, Darren J.
Publicado 2023

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

por Wang, Xinhe, Becker, Katelyn, Levine, Nathan, Zhang, Michelle, Lieberman, Andrew P., Moore, Darren J., Ma, Jiyan
Publicado 2019

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism

por Podhajska, Agata, Musso, Alessandra, Trancikova, Alzbeta, Stafa, Klodjan, Moser, Roger, Sonnay, Sarah, Glauser, Liliane, Moore, Darren J.
Publicado 2012

Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

por Trancikova, Alzbeta, Mamais, Adamantios, Webber, Philip J., Stafa, Klodjan, Tsika, Elpida, Glauser, Liliane, West, Andrew B., Bandopadhyay, Rina, Moore, Darren J.
Publicado 2012

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

por Nguyen, An Phu Tran, Tsika, Elpida, Kelly, Kaela, Levine, Nathan, Chen, Xi, West, Andrew B., Boularand, Sylviane, Barneoud, Pascal, Moore, Darren J.
Publicado 2020

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

por Biskup, Saskia, Moore, Darren J, Rea, Alexis, Lorenz-Deperieux, Bettina, Coombes, Candice E, Dawson, Valina L, Dawson, Ted M, West, Andrew B
Publicado 2007

Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality

por Sargent, Dorian, Cunningham, Lindsey A, Dues, Dylan J, Ma, Yue, Kordich, Jennifer J, Mercado, Gabriela, Brundin, Patrik, Cowell, Rita M, Moore, Darren J
Publicado 2021

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

por Xiong, Yulan, Coombes, Candice E., Kilaru, Austin, Li, Xiaojie, Gitler, Aaron D., Bowers, William J., Dawson, Valina L., Dawson, Ted M., Moore, Darren J.
Publicado 2010

Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

por Chen, Xi, Kordich, Jennifer K., Williams, Erin T., Levine, Nathan, Cole-Strauss, Allyson, Marshall, Lee, Labrie, Viviane, Ma, Jiyan, Lipton, Jack W., Moore, Darren J.
Publicado 2019

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

por Stafa, Klodjan, Tsika, Elpida, Moser, Roger, Musso, Alessandra, Glauser, Liliane, Jones, Amy, Biskup, Saskia, Xiong, Yulan, Bandopadhyay, Rina, Dawson, Valina L., Dawson, Ted M., Moore, Darren J.
Publicado 2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

por Tsika, Elpida, Glauser, Liliane, Moser, Roger, Fiser, Aris, Daniel, Guillaume, Sheerin, Una-Marie, Lees, Andrew, Troncoso, Juan C., Lewis, Patrick A., Bandopadhyay, Rina, Schneider, Bernard L., Moore, Darren J.
Publicado 2014