Novel technologies for vaccine development

por Morabito, Kaitlyn M.
Publicado 2021

Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus K(d)M2(82-90) Epitope Is Transfer Dose-Dependent

por Morabito, Kaitlyn M., Erez, Noam, Graham, Barney S., Ruckwardt, Tracy J.
Publicado 2016

Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response

por Ruckwardt, Tracy J., Malloy, Allison M. W., Morabito, Kaitlyn M., Graham, Barney S.
Publicado 2014

Neonatal mice possess two phenotypically and functionally distinct lung-migratory CD103+ dendritic cell populations following respiratory infection

por Ruckwardt, Tracy J, Morabito, Kaitlyn M, Bar-Haim, Erez, Nair, Deepika, Graham, Barney S
Publicado 2017

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

por Morabito, Kaitlyn M., Ruckwardt, Tracy R., Redwood, Alec J., Moin, Syed M., Price, David A., Graham, Barney S.
Publicado 2016

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

por Liu, Jie, Haddad, Elias K., Marceau, Joshua, Morabito, Kaitlyn M., Rao, Srinivas S., Filali-Mouhim, Ali, Sekaly, Rafick-Pierre, Graham, Barney S.
Publicado 2016

Memory Inflation Drives Tissue-Resident Memory CD8(+) T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

por Morabito, Kaitlyn M., Ruckwardt, Tracy J., Bar-Haim, Erez, Nair, Deepika, Moin, Syed M., Redwood, Alec J., Price, David A., Graham, Barney S.
Publicado 2018

Epitope-Specific Serological Assays for RSV: Conformation Matters

por Phung, Emily, Chang, Lauren A., Morabito, Kaitlyn M., Kanekiyo, Masaru, Chen, Man, Nair, Deepika, Kumar, Azad, Chen, Grace L., Ledgerwood, Julie E., Graham, Barney S., Ruckwardt, Tracy J.
Publicado 2019

EV-D68 virus-like particle vaccines elicit cross-clade neutralizing antibodies that inhibit infection and block dissemination

por Krug, Peter W., Wang, Lingshu, Shi, Wei, Kong, Wing-Pui, Moss, Daniel L., Yang, Eun Sung, Fisher, Brian E., Morabito, Kaitlyn M., Mascola, John R., Kanekiyo, Masaru, Graham, Barney S., Ruckwardt, Tracy J.
Publicado 2023

Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development

por Loomis, Rebecca J., Stewart-Jones, Guillaume B. E., Tsybovsky, Yaroslav, Caringal, Ria T., Morabito, Kaitlyn M., McLellan, Jason S., Chamberlain, Amy L., Nugent, Sean T., Hutchinson, Geoffrey B., Kueltzo, Lisa A., Mascola, John R., Graham, Barney S.
Publicado 2020

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

por Bollman, Brooke, Nunna, Naveen, Bahl, Kapil, Hsiao, Chiaowen Joyce, Bennett, Hamilton, Butler, Scott, Foreman, Bryant, Burgomaster, Katherine E., Aleshnick, Maya, Kong, Wing-Pui, Fisher, Brian E., Ruckwardt, Tracy J., Morabito, Kaitlyn M., Graham, Barney S., Dowd, Kimberly A., Pierson, Theodore C., Carfi, Andrea
Publicado 2023

Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine

por Loomis, Rebecca J., DiPiazza, Anthony T., Falcone, Samantha, Ruckwardt, Tracy J., Morabito, Kaitlyn M., Abiona, Olubukola M., Chang, Lauren A., Caringal, Ria T., Presnyak, Vladimir, Narayanan, Elisabeth, Tsybovsky, Yaroslav, Nair, Deepika, Hutchinson, Geoffrey B., Stewart-Jones, Guillaume B. E., Kueltzo, Lisa A., Himansu, Sunny, Mascola, John R., Carfi, Andrea, Graham, Barney S.
Publicado 2021

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

por Shan, Chao, Muruato, Antonio E., Jagger, Brett W., Richner, Justin, Nunes, Bruno T. D., Medeiros, Daniele B. A., Xie, Xuping, Nunes, Jannyce G. C., Morabito, Kaitlyn M., Kong, Wing-Pui, Pierson, Theodore C., Barrett, Alan D., Weaver, Scott C., Rossi, Shannan L., Vasconcelos, Pedro F. C., Graham, Barney S., Diamond, Michael S., Shi, Pei-Yong
Publicado 2017

COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

por DiPiazza, Anthony T., Leist, Sarah R., Abiona, Olubukola M., Moliva, Juan I., Werner, Anne, Minai, Mahnaz, Nagata, Bianca M., Bock, Kevin W., Phung, Emily, Schäfer, Alexandra, Dinnon, Kenneth H., Chang, Lauren A., Loomis, Rebecca J., Boyoglu-Barnum, Seyhan, Alvarado, Gabriela S., Sullivan, Nancy J., Edwards, Darin K., Morabito, Kaitlyn M., Mascola, John R., Carfi, Andrea, Corbett, Kizzmekia S., Moore, Ian N., Baric, Ralph S., Graham, Barney S., Ruckwardt, Tracy J.
Publicado 2021

Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient

por Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs W, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, Bont, Louis J
Publicado 2022

Development of a potent Zika virus vaccine using self-amplifying messenger RNA

por Luisi, Kate, Morabito, Kaitlyn M., Burgomaster, Katherine E., Sharma, Mayuri, Kong, Wing-Pui, Foreman, Bryant M., Patel, Sonal, Fisher, Brian, Aleshnick, Maya A., Laliberte, Jason, Wallace, Madison, Ruckwardt, Tracy J., Gordon, David N., Linton, Christine, Ruggiero, Nicole, Cohen, Jessica L., Johnson, Russell, Aggarwal, Kunal, Ko, Sung-Youl, Yang, Eun Sung, Pelc, Rebecca S., Dowd, Kimberly A., O’Hagan, Derek, Ulmer, Jeffrey, Mossman, Sally, Sambor, Anna, Lepine, Edith, Mascola, John R., Pierson, Theodore C., Graham, Barney S., Yu, Dong
Publicado 2020

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

por Gaudinski, Martin R, Houser, Katherine V, Morabito, Kaitlyn M, Hu, Zonghui, Yamshchikov, Galina, Rothwell, Ro Shauna, Berkowitz, Nina, Mendoza, Floreliz, Saunders, Jamie G, Novik, Laura, Hendel, Cynthia S, Holman, LaSonji A, Gordon, Ingelise J, Cox, Josephine H, Edupuganti, Srilatha, McArthur, Monica A, Rouphael, Nadine G, Lyke, Kirsten E, Cummings, Ginny E, Sitar, Sandra, Bailer, Robert T, Foreman, Bryant M, Burgomaster, Katherine, Pelc, Rebecca S, Gordon, David N, DeMaso, Christina R, Dowd, Kimberly A, Laurencot, Carolyn, Schwartz, Richard M, Mascola, John R, Graham, Barney S, Pierson, Theodore C, Ledgerwood, Julie E, Chen, Grace L
Publicado 2018

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

por Jackson, Lisa A., Anderson, Evan J., Rouphael, Nadine G., Roberts, Paul C., Makhene, Mamodikoe, Coler, Rhea N., McCullough, Michele P., Chappell, James D., Denison, Mark R., Stevens, Laura J., Pruijssers, Andrea J., McDermott, Adrian, Flach, Britta, Doria-Rose, Nicole A., Corbett, Kizzmekia S., Morabito, Kaitlyn M., O’Dell, Sijy, Schmidt, Stephen D., Swanson, Phillip A., Padilla, Marcelino, Mascola, John R., Neuzil, Kathleen M., Bennett, Hamilton, Sun, Wellington, Peters, Etza, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Buchanan, Wendy, Pikaart-Tautges, Rhonda, Ledgerwood, Julie E., Graham, Barney S., Beigel, John H.
Publicado 2020

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

por Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B., Wu, Kai, Henry, Carole, Bahi, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D., Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A., Loomis, Rebecca J., Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K., Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L., Stevens, Laura J., Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A., Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S., Nason, Martha C., Ruckwardt, Tracy J., McLellan, Jason S., Denison, Mark R., Chappell, James D., Moore, Ian N., Morabito, Kaitlyn M., Mascola, John R., Baric, Ralph S., Carfi, Andrea, Graham, Barney S.
Publicado 2020

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

por Corbett, Kizzmekia S., Flynn, Barbara, Foulds, Kathryn E., Francica, Joseph R., Boyoglu-Barnum, Seyhan, Werner, Anne P., Flach, Britta, O’Connell, Sarah, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Andersen, Hanne, Martinez, David R., Noe, Amy T., Douek, Naomi, Donaldson, Mitzi M., Nji, Nadesh N., Alvarado, Gabriela S., Edwards, Darin K., Flebbe, Dillon R., Lamb, Evan, Doria-Rose, Nicole A., Lin, Bob C., Louder, Mark K., O’Dell, Sijy, Schmidt, Stephen D., Phung, Emily, Chang, Lauren A., Yap, Christina, Todd, John-Paul M., Pessaint, Laurent, Van Ry, Alex, Browne, Shanai, Greenhouse, Jack, Putman-Taylor, Tammy, Strasbaugh, Amanda, Campbell, Tracey-Ann, Cook, Anthony, Dodson, Alan, Steingrebe, Katelyn, Shi, Wei, Zhang, Yi, Abiona, Olubukola M., Wang, Lingshu, Pegu, Amarendra, Yang, Eun Sung, Leung, Kwanyee, Zhou, Tongqing, Teng, I-Ting, Widge, Alicia, Gordon, Ingelise, Novik, Laura, Gillespie, Rebecca A., Loomis, Rebecca J., Moliva, Juan I., Stewart-Jones, Guillaume, Himansu, Sunny, Kong, Wing-Pui, Nason, Martha C., Morabito, Kaitlyn M., Ruckwardt, Tracy J., Ledgerwood, Julie E., Gaudinski, Martin R., Kwong, Peter D., Mascola, John R., Carfi, Andrea, Lewis, Mark G., Baric, Ralph S., McDermott, Adrian, Moore, Ian N., Sullivan, Nancy J., Roederer, Mario, Seder, Robert A., Graham, Barney S.
Publicado 2020