Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

por Zingales, Bianca, Miles, Michael A, Moraes, Carolina B, Luquetti, Alejandro, Guhl, Felipe, Schijman, Alejandro G, Ribeiro, Isabela
Publicado 2014

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

por Alcântara, Laura M., Ferreira, Thalita C. S., Fontana, Vanessa, Chatelain, Eric, Moraes, Carolina B., Freitas-Junior, Lucio H.
Publicado 2020

Quantum dots: a new tool for anti-malarial drug assays

por Ku, Min-Je, Dossin, Fernando M, Choi, Youngseon, Moraes, Carolina B, Ryu, Jiyoung, Song, Rita, Freitas-Junior, Lucio H
Publicado 2011

Transcription Sites Are Developmentally Regulated during the Asexual Cycle of Plasmodium falciparum

por Moraes, Carolina B., Dorval, Thierry, Contreras-Dominguez, Mónica, Dossin, Fernando de M., Hansen, Michael A. E., Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado 2013

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

por Moraes, Carolina B., Giardini, Miriam A., Kim, Hwayoung, Franco, Caio H., Araujo-Junior, Adalberto M., Schenkman, Sergio, Chatelain, Eric, Freitas-Junior, Lucio H.
Publicado 2014

Automated Nuclear Analysis of Leishmania major Telomeric Clusters Reveals Changes in Their Organization during the Parasite's Life Cycle

por Dossin, Fernando de M., Dufour, Alexandre, Dusch, Elodie, Siqueira-Neto, Jair L., Moraes, Carolina B., Yang, Gyong Seon, Cano, Maria Isabel, Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado 2008

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

por Franco, Caio H., Warhurst, David C., Bhattacharyya, Tapan, Au, Ho Y.A., Le, Hai, Giardini, Miriam A., Pascoalino, Bruno S., Torrecilhas, Ana Claudia, Romera, Lavinia M.D., Madeira, Rafael Pedro, Schenkman, Sergio, Freitas-Junior, Lucio H., Chatelain, Eric, Miles, Michael A., Moraes, Carolina B.
Publicado 2020

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

por Di Pisa, Flavio, Landi, Giacomo, Dello Iacono, Lucia, Pozzi, Cecilia, Borsari, Chiara, Ferrari, Stefania, Santucci, Matteo, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Moraes, Carolina B., Alcantara, Laura M., Fontana, Vanessa, Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Behrens, Birte, Pöhner, Ina, Wade, Rebecca C., Costi, Maria Paola, Mangani, Stefano
Publicado 2017

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

por Freire, Marjorie C. L. C., Noske, Gabriela D., Bitencourt, Natália V., Sanches, Paulo R. S., Santos-Filho, Norival A., Gawriljuk, Victor O., de Souza, Eduardo P., Nogueira, Victor H. R., de Godoy, Mariana O., Nakamura, Aline M., Fernandes, Rafaela S., Godoy, Andre S., Juliano, Maria A., Peres, Bianca M., Barbosa, Cecília G., Moraes, Carolina B., Freitas-Junior, Lucio H. G., Cilli, Eduardo M., Guido, Rafael V. C., Oliva, Glaucius
Publicado 2021

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

por Linciano, Pasquale, Dawson, Alice, Pöhner, Ina, Costa, David M., Sá, Monica S., Cordeiro-da-Silva, Anabela, Luciani, Rosaria, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Gribbon, Philip, Reinshagen, Jeanette, Wolf, Markus, Behrens, Birte, Hannaert, Véronique, Michels, Paul A. M., Nerini, Erika, Pozzi, Cecilia, di Pisa, Flavio, Landi, Giacomo, Santarem, Nuno, Ferrari, Stefania, Saxena, Puneet, Lazzari, Sandra, Cannazza, Giuseppe, Freitas-Junior, Lucio H., Moraes, Carolina B., Pascoalino, Bruno S., Alcântara, Laura M., Bertolacini, Claudia P., Fontana, Vanessa, Wittig, Ulrike, Müller, Wolfgang, Wade, Rebecca C., Hunter, William N., Mangani, Stefano, Costantino, Luca, Costi, Maria P.
Publicado 2017

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

por Moraes, Carolina B., Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Calogeropoulou, Theodora, Prousis, Kyriakos C., Mangani, Stefano, Di Pisa, Flavio, Landi, Giacomo, Iacono, Lucia Dello, Pozzi, Cecilia, Freitas-Junior, Lucio H., dos Santos Pascoalino, Bruno, Bertolacini, Claudia P., Behrens, Birte, Keminer, Oliver, Leu, Jennifer, Wolf, Markus, Reinshagen, Jeanette, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Venturelli, Alberto, Wrigley, Stephen, Karunakaran, Deepa, Kebede, Bethlehem, Pöhner, Ina, Müller, Wolfgang, Panecka-Hofman, Joanna, Wade, Rebecca C., Fenske, Martina, Clos, Joachim, Alunda, José María, Corral, María Jesús, Uliassi, Elisa, Bolognesi, Maria Laura, Linciano, Pasquale, Quotadamo, Antonio, Ferrari, Stefania, Santucci, Matteo, Borsari, Chiara, Costi, Maria Paola, Gul, Sheraz
Publicado 2019