Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference

por Lefrancois, Stephane, Canuel, Maryssa, Zeng, Jibin, Morales, Carlos R.
Publicado 2005

Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model

por Oliveira, Regiana, Hermo, Louis, Pshezhetsky, Alexey V., Morales, Carlos R.
Publicado 2018

Evaluation of Deep Learning Methods in a Dual Prediction Scheme to Reduce Transmission Data in a WSN

por Morales, Carlos R., Rangel de Sousa, Fernando, Brusamarello, Valner, Fernandes, Nestor C.
Publicado 2021

Effects of Heparan sulfate acetyl-CoA: Alpha-glucosaminide N-acetyltransferase (HGSNAT) inactivation on the structure and function of epithelial and immune cells of the testis and...

por Carvelli, Lorena, Hermo, Louis, O’Flaherty, Cristian, Oko, Richard, Pshezhetsky, Alexey V., Morales, Carlos R.
Publicado 2023

Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice

por Devader, Christelle, Moreno, Sébastien, Roulot, Morgane, Deval, Emmanuel, Dix, Thomas, Morales, Carlos R., Mazella, Jean
Publicado 2016

Atypical juvenile presentation of G(M2) gangliosidosis AB in a patient compound-heterozygote for c.259G > T and c.164C > T mutations in the GM2A gene()

por Martins, Carla, Brunel-Guitton, Catherine, Lortie, Anne, Gauvin, France, Morales, Carlos R., Mitchell, Grant A., Pshezhetsky, Alexey V.
Publicado 2017

Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligom...

por Carvelli, Lorena, Aguilera, Andrea Carolina, Zyla, Leila, Pereyra, Laura Lucía, Morales, Carlos R., Hermo, Louis, Sosa, Miguel A.
Publicado 2021

Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism

por Martin-DeLeon, Patricia A, Zhang, Hong, Morales, Carlos R, Zhao, Yutong, Rulon, Michelle, Barnoski, Barry L, Chen, Hong, Galileo, Deni S
Publicado 2005

Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

por Morales, Carlos R., Grigoryeva, Lubov S., Pan, Xuefang, Bruno, Luigi, Hickson, Gilles, Ngo, Michael H., McMaster, Christopher R., Samuels, Mark E., Pshezhetsky, Alexey V.
Publicado 2014

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking

por Yang, Miao, Virassamy, Balaji, Vijayaraj, Swarna Lekha, Lim, Yoon, Saadipour, Khalil, Wang, Yan-Jiang, Han, Yan-Chuang, Zhong, Jin-Hua, Morales, Carlos R., Zhou, Xin-Fu
Publicado 2013

Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption

por Kho, Ikhui, Demina, Ekaterina P., Pan, Xuefang, Londono, Irene, Cairo, Christopher W., Sturiale, Luisa, Palmigiano, Angelo, Messina, Angela, Garozzo, Domenico, Ung, Roth-Visal, Mac-Way, Fabrice, Bonneil, Éric, Thibault, Pierre, Lemaire, Mathieu, Morales, Carlos R., Pshezhetsky, Alexey V.
Publicado 2023

Mice Doubly-Deficient in Lysosomal Hexosaminidase A and Neuraminidase 4 Show Epileptic Crises and Rapid Neuronal Loss

por Seyrantepe, Volkan, Lema, Pablo, Caqueret, Aurore, Dridi, Larbi, Bel Hadj, Samar, Carpentier, Stephane, Boucher, Francine, Levade, Thierry, Carmant, Lionel, Gravel, Roy A., Hamel, Edith, Vachon, Pascal, Di Cristo, Graziella, Michaud, Jacques L., Morales, Carlos R., Pshezhetsky, Alexey V.
Publicado 2010

Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

por Pan, Xuefang, Taherzadeh, Mahsa, Bose, Poulomee, Heon-Roberts, Rachel, Nguyen, Annie L.A., Xu, TianMeng, Pará, Camila, Yamanaka, Yojiro, Priestman, David A., Platt, Frances M., Khan, Shaukat, Fnu, Nidhi, Tomatsu, Shunji, Morales, Carlos R., Pshezhetsky, Alexey V.
Publicado 2022

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages

por Toboz, Phoenix, Amiri, Mehdi, Tabatabaei, Negar, Dufour, Catherine R., Kim, Seung Hyeon, Fillebeen, Carine, Ayemoba, Charles E., Khoutorsky, Arkady, Nairz, Manfred, Shao, Lijian, Pajcini, Kostandin V., Kim, Ki-Wook, Giguère, Vincent, Oliveira, Regiana L., Constante, Marco, Santos, Manuela M., Morales, Carlos R., Pantopoulos, Kostas, Sonenberg, Nahum, Pinho, Sandra, Tahmasebi, Soroush
Publicado 2022

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function

por Da Silva, Afitz, Dort, Junio, Orfi, Zakaria, Pan, Xuefang, Huang, Sjanie, Kho, Ikhui, Heckel, Emilie, Muscarnera, Giacomo, van Vliet, Patrick Piet, Sturiale, Luisa, Messina, Angela, Romeo, Donata Agata, van Karnebeek, Clara D.M., Wen, Xiao-Yan, Hinek, Aleksander, Molina, Thomas, Andelfinger, Gregor, Ellezam, Benjamin, Yamanaka, Yojiro, Olivos, Hernando J., Morales, Carlos R., Joyal, Jean-Sébastien, Lefeber, Dirk J., Garozzo, Domenico, Dumont, Nicolas A., Pshezhetsky, Alexey V.
Publicado 2023